How Do Gangliosides Regulate RTKs Signaling?

Gangliosides, the glycosphingolipids carrying one or several sialic acid residues, are located on the outer leaflet of the plasma membrane in glycolipid-enriched microdomains, where they interact with molecules of signal transduction pathways including receptors tyrosine kinases (RTKs). The role of...

Descripción completa

Detalles Bibliográficos
Autores principales: Julien, Sylvain, Bobowski, Marie, Steenackers, Agata, Le Bourhis, Xuefen, Delannoy, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972652/
https://www.ncbi.nlm.nih.gov/pubmed/24709879
http://dx.doi.org/10.3390/cells2040751
_version_ 1782309606278561792
author Julien, Sylvain
Bobowski, Marie
Steenackers, Agata
Le Bourhis, Xuefen
Delannoy, Philippe
author_facet Julien, Sylvain
Bobowski, Marie
Steenackers, Agata
Le Bourhis, Xuefen
Delannoy, Philippe
author_sort Julien, Sylvain
collection PubMed
description Gangliosides, the glycosphingolipids carrying one or several sialic acid residues, are located on the outer leaflet of the plasma membrane in glycolipid-enriched microdomains, where they interact with molecules of signal transduction pathways including receptors tyrosine kinases (RTKs). The role of gangliosides in the regulation of signal transduction has been reported in many cases and in a large number of cell types. In this review, we summarize the current knowledge on the biosynthesis of gangliosides and the mechanism by which they regulate RTKs signaling.
format Online
Article
Text
id pubmed-3972652
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-39726522014-04-07 How Do Gangliosides Regulate RTKs Signaling? Julien, Sylvain Bobowski, Marie Steenackers, Agata Le Bourhis, Xuefen Delannoy, Philippe Cells Review Gangliosides, the glycosphingolipids carrying one or several sialic acid residues, are located on the outer leaflet of the plasma membrane in glycolipid-enriched microdomains, where they interact with molecules of signal transduction pathways including receptors tyrosine kinases (RTKs). The role of gangliosides in the regulation of signal transduction has been reported in many cases and in a large number of cell types. In this review, we summarize the current knowledge on the biosynthesis of gangliosides and the mechanism by which they regulate RTKs signaling. MDPI 2013-12-06 /pmc/articles/PMC3972652/ /pubmed/24709879 http://dx.doi.org/10.3390/cells2040751 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Julien, Sylvain
Bobowski, Marie
Steenackers, Agata
Le Bourhis, Xuefen
Delannoy, Philippe
How Do Gangliosides Regulate RTKs Signaling?
title How Do Gangliosides Regulate RTKs Signaling?
title_full How Do Gangliosides Regulate RTKs Signaling?
title_fullStr How Do Gangliosides Regulate RTKs Signaling?
title_full_unstemmed How Do Gangliosides Regulate RTKs Signaling?
title_short How Do Gangliosides Regulate RTKs Signaling?
title_sort how do gangliosides regulate rtks signaling?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972652/
https://www.ncbi.nlm.nih.gov/pubmed/24709879
http://dx.doi.org/10.3390/cells2040751
work_keys_str_mv AT juliensylvain howdogangliosidesregulatertkssignaling
AT bobowskimarie howdogangliosidesregulatertkssignaling
AT steenackersagata howdogangliosidesregulatertkssignaling
AT lebourhisxuefen howdogangliosidesregulatertkssignaling
AT delannoyphilippe howdogangliosidesregulatertkssignaling

Ejemplares similares