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Linking Metabolic Abnormalities to Apoptotic Pathways in Beta Cells in Type 2 Diabetes

Pancreatic beta-cell apoptosis is an important feature of islets in type 2 diabetes. Apoptosis can occur through two major pathways, the extrinsic or death receptor mediated pathway, and the intrinsic or Bcl-2-regulated pathway. Hyperglycaemia, hyperlipidaemia and islet amyloid poly-peptide (IAPP) r...

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Detalles Bibliográficos
Autores principales:	Wali, Jibran A., Masters, Seth L., Thomas, Helen E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2013
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972679/ https://www.ncbi.nlm.nih.gov/pubmed/24709700 http://dx.doi.org/10.3390/cells2020266

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