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Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch
In sensory neurons, mechanotransduction is sensitive, fast and requires mechanosensitive ion channels. Here we develop a new method to directly monitor mechanotransduction at defined regions of the cell-substrate interface. We show that molecular-scale (~13 nm) displacements are sufficient to gate m...
Autores principales: | Poole, Kate, Herget, Regina, Lapatsina, Liudmila, Ngo, Ha-Duong, Lewin, Gary R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973071/ https://www.ncbi.nlm.nih.gov/pubmed/24662763 http://dx.doi.org/10.1038/ncomms4520 |
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