Longikaurin A, a natural ent-kaurane, induces G2/M phase arrest via downregulation of Skp2 and apoptosis induction through ROS/JNK/c-Jun pathway in hepatocellular carcinoma cells

Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer, and is also highly resistant to conventional chemotherapy treatments. In this study, we report that Longikaurin A (LK-A), an ent-kaurane diterpenoid isolated from the plant Isodon ternifolius, induced cell cycle arrest a...

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Detalles Bibliográficos
Autores principales: Liao, Y-J, Bai, H-Y, Li, Z-H, Zou, J, Chen, J-W, Zheng, F, Zhang, J-X, Mai, S-J, Zeng, M-S, Sun, H-D, Pu, J-X, Xie, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973226/
https://www.ncbi.nlm.nih.gov/pubmed/24651440
http://dx.doi.org/10.1038/cddis.2014.66

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973226/
https://www.ncbi.nlm.nih.gov/pubmed/24651440
http://dx.doi.org/10.1038/cddis.2014.66

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