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Longikaurin A, a natural ent-kaurane, induces G2/M phase arrest via downregulation of Skp2 and apoptosis induction through ROS/JNK/c-Jun pathway in hepatocellular carcinoma cells
Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer, and is also highly resistant to conventional chemotherapy treatments. In this study, we report that Longikaurin A (LK-A), an ent-kaurane diterpenoid isolated from the plant Isodon ternifolius, induced cell cycle arrest a...
Autores principales: | Liao, Y-J, Bai, H-Y, Li, Z-H, Zou, J, Chen, J-W, Zheng, F, Zhang, J-X, Mai, S-J, Zeng, M-S, Sun, H-D, Pu, J-X, Xie, D |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973226/ https://www.ncbi.nlm.nih.gov/pubmed/24651440 http://dx.doi.org/10.1038/cddis.2014.66 |
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