Amyloidogenic variant of apolipoprotein A-I elicits cellular stress by attenuating the protective activity of angiogenin

Amyloidogenic ‘gain-of-function' mutations in apolipoprotein A-I (ApoA-I) gene (APOA1) result in systemic amyloidosis characterized by aggregate deposition and eventually cell death. However, how amyloidogenic variants of ApoA-I induce cell death is unknown. Here we report that one of the mecha...

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Detalles Bibliográficos
Autores principales: Del Giudice, R, Monti, D M, Sarcinelli, C, Arciello, A, Piccoli, R, Hu, G-F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973227/
https://www.ncbi.nlm.nih.gov/pubmed/24603325
http://dx.doi.org/10.1038/cddis.2014.45

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973227/
https://www.ncbi.nlm.nih.gov/pubmed/24603325
http://dx.doi.org/10.1038/cddis.2014.45

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