Stronger proteasomal inhibition and higher CHOP induction are responsible for more effective induction of paraptosis by dimethoxycurcumin than curcumin

Although curcumin suppresses the growth of a variety of cancer cells, its poor absorption and low systemic bioavailability have limited its translation into clinics as an anticancer agent. In this study, we show that dimethoxycurcumin (DMC), a methylated, more stable analog of curcumin, is significa...

Descripción completa

Detalles Bibliográficos
Autores principales: Yoon, M J, Kang, Y J, Lee, J A, Kim, I Y, Kim, M A, Lee, Y S, Park, J H, Lee, B Y, Kim, I A, Kim, H S, Kim, S-A, Yoon, A-R, Yun, C-O, Kim, E-Y, Lee, K, Choi, K S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973237/
https://www.ncbi.nlm.nih.gov/pubmed/24625971
http://dx.doi.org/10.1038/cddis.2014.85

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973237/
https://www.ncbi.nlm.nih.gov/pubmed/24625971
http://dx.doi.org/10.1038/cddis.2014.85

Ejemplares similares