SKLB-163, a new benzothiazole-2-thiol derivative, exhibits potent anticancer activity by affecting RhoGDI/JNK-1 signaling pathway

Small-molecule inhibitors are an attractive therapeutic approach for most types of human cancers. SKLB-163, a novel benzothiazole-2-thiol derivative, was developed via computer-aided drug design and de novo synthesis. MTT assay showed it had potent anti-proliferative activity on various human cancer...

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Detalles Bibliográficos
Autores principales: Peng, X, Xie, G, Wang, Z, Lin, H, Zhou, T, Xiang, P, Jiang, Y, Yang, S, Wei, Y, Yu, L, Zhao, Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973246/
https://www.ncbi.nlm.nih.gov/pubmed/24675461
http://dx.doi.org/10.1038/cddis.2014.107

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