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An arginine-aspartate network in the active site of bacterial TruB is critical for catalyzing pseudouridine formation

Pseudouridine synthases introduce the most common RNA modification and likely use the same catalytic mechanism. Besides a catalytic aspartate residue, the contributions of other residues for catalysis of pseudouridine formation are poorly understood. Here, we have tested the role of a conserved basi...

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Detalles Bibliográficos
Autores principales:	Friedt, Jenna, Leavens, Fern M. V., Mercier, Evan, Wieden, Hans-Joachim, Kothe, Ute
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973310/ https://www.ncbi.nlm.nih.gov/pubmed/24371284 http://dx.doi.org/10.1093/nar/gkt1331

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