An online bioinformatics tool predicts zinc finger and TALE nuclease off-target cleavage

Although engineered nucleases can efficiently cleave intracellular DNA at desired target sites, major concerns remain on potential ‘off-target’ cleavage that may occur throughout the genome. We developed an online tool: predicted report of genome-wide nuclease off-target sites (PROGNOS) that effecti...

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Detalles Bibliográficos
Autores principales: Fine, Eli J., Cradick, Thomas J., Zhao, Charles L., Lin, Yanni, Bao, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973315/
https://www.ncbi.nlm.nih.gov/pubmed/24381193
http://dx.doi.org/10.1093/nar/gkt1326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973315/
https://www.ncbi.nlm.nih.gov/pubmed/24381193
http://dx.doi.org/10.1093/nar/gkt1326

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