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An online bioinformatics tool predicts zinc finger and TALE nuclease off-target cleavage

Although engineered nucleases can efficiently cleave intracellular DNA at desired target sites, major concerns remain on potential ‘off-target’ cleavage that may occur throughout the genome. We developed an online tool: predicted report of genome-wide nuclease off-target sites (PROGNOS) that effecti...

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Detalles Bibliográficos
Autores principales:	Fine, Eli J., Cradick, Thomas J., Zhao, Charles L., Lin, Yanni, Bao, Gang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Methods Online
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973315/ https://www.ncbi.nlm.nih.gov/pubmed/24381193 http://dx.doi.org/10.1093/nar/gkt1326

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