Base excision repair of oxidative DNA damage coupled with removal of a CAG repeat hairpin attenuates trinucleotide repeat expansion

Trinucleotide repeat (TNR) expansion is responsible for numerous human neurodegenerative diseases. However, the underlying mechanisms remain unclear. Recent studies have shown that DNA base excision repair (BER) can mediate TNR expansion and deletion by removing base lesions in different locations o...

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Detalles Bibliográficos
Autores principales: Xu, Meng, Lai, Yanhao, Torner, Justin, Zhang, Yanbin, Zhang, Zunzhen, Liu, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973345/
https://www.ncbi.nlm.nih.gov/pubmed/24423876
http://dx.doi.org/10.1093/nar/gkt1372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973345/
https://www.ncbi.nlm.nih.gov/pubmed/24423876
http://dx.doi.org/10.1093/nar/gkt1372

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