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Amphiphilic drug interactions with model cellular membranes are influenced by lipid chain-melting temperature
Small-molecule amphiphilic species such as many drug molecules frequently exhibit low-to-negligible aqueous solubility, and generally have no identified transport proteins assisting their distribution, yet are able to rapidly penetrate significant distances into patient tissue and even cross the blo...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973356/ https://www.ncbi.nlm.nih.gov/pubmed/24621813 http://dx.doi.org/10.1098/rsif.2013.1062 |