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Androgens Involvement in the Pathogenesis of Renal Stones Formation
OBJECTIVE: The potential role for the gonadal steroids in the pathogenesis of urolithiasis, higher mean of plasma oxalate concentration and kidney calcium oxalate deposition influenced by androgens in men has been proposed. In this study, the serum levels of steroid hormones as a pathogenesis of thi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973622/ https://www.ncbi.nlm.nih.gov/pubmed/24695421 http://dx.doi.org/10.1371/journal.pone.0093790 |
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author | Naghii, Mohammad Reza Babaei, Mnasour Hedayati, Mehdi |
author_facet | Naghii, Mohammad Reza Babaei, Mnasour Hedayati, Mehdi |
author_sort | Naghii, Mohammad Reza |
collection | PubMed |
description | OBJECTIVE: The potential role for the gonadal steroids in the pathogenesis of urolithiasis, higher mean of plasma oxalate concentration and kidney calcium oxalate deposition influenced by androgens in men has been proposed. In this study, the serum levels of steroid hormones as a pathogenesis of this condition in male patients with active renal stone disease compared with controls was investigated. METHODS: Forty patients diagnosed with renal stones and hospitalized for further clinical treatments or referred to our office after ultrasonographic evaluations participated in the study. Forty six healthy subjects served as controls. Steroid sex hormones in the plasma samples including testosterone, free testosterone, dihydrotestosterone, estradiol, and sex hormone binding globulin were analyzed. RESULTS: A significant difference was observed between patients and the control subjects regarding serum testosterone, free testosterone, dihydrotestosterone, estradiol, and sex hormone binding globulin. CONCLUSIONS: Based on the results, a higher androgens level was diagnosed in renal stone patients, indicating a possibility of a substantial pathogenic role of testosterone, free testosterone, and dihydrotestosterone involvement in the pathogenesis of renal stones formation. Therefore, data presentation and further investigation on the relation between male steroids and urolithiasis is of importance and should be considered in evaluation of the etiology of the disease. |
format | Online Article Text |
id | pubmed-3973622 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39736222014-04-04 Androgens Involvement in the Pathogenesis of Renal Stones Formation Naghii, Mohammad Reza Babaei, Mnasour Hedayati, Mehdi PLoS One Research Article OBJECTIVE: The potential role for the gonadal steroids in the pathogenesis of urolithiasis, higher mean of plasma oxalate concentration and kidney calcium oxalate deposition influenced by androgens in men has been proposed. In this study, the serum levels of steroid hormones as a pathogenesis of this condition in male patients with active renal stone disease compared with controls was investigated. METHODS: Forty patients diagnosed with renal stones and hospitalized for further clinical treatments or referred to our office after ultrasonographic evaluations participated in the study. Forty six healthy subjects served as controls. Steroid sex hormones in the plasma samples including testosterone, free testosterone, dihydrotestosterone, estradiol, and sex hormone binding globulin were analyzed. RESULTS: A significant difference was observed between patients and the control subjects regarding serum testosterone, free testosterone, dihydrotestosterone, estradiol, and sex hormone binding globulin. CONCLUSIONS: Based on the results, a higher androgens level was diagnosed in renal stone patients, indicating a possibility of a substantial pathogenic role of testosterone, free testosterone, and dihydrotestosterone involvement in the pathogenesis of renal stones formation. Therefore, data presentation and further investigation on the relation between male steroids and urolithiasis is of importance and should be considered in evaluation of the etiology of the disease. Public Library of Science 2014-04-02 /pmc/articles/PMC3973622/ /pubmed/24695421 http://dx.doi.org/10.1371/journal.pone.0093790 Text en © 2014 Naghii et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Naghii, Mohammad Reza Babaei, Mnasour Hedayati, Mehdi Androgens Involvement in the Pathogenesis of Renal Stones Formation |
title | Androgens Involvement in the Pathogenesis of Renal Stones Formation |
title_full | Androgens Involvement in the Pathogenesis of Renal Stones Formation |
title_fullStr | Androgens Involvement in the Pathogenesis of Renal Stones Formation |
title_full_unstemmed | Androgens Involvement in the Pathogenesis of Renal Stones Formation |
title_short | Androgens Involvement in the Pathogenesis of Renal Stones Formation |
title_sort | androgens involvement in the pathogenesis of renal stones formation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973622/ https://www.ncbi.nlm.nih.gov/pubmed/24695421 http://dx.doi.org/10.1371/journal.pone.0093790 |
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