Transcription Factor Nrf1 Is Topologically Repartitioned across Membranes to Enable Target Gene Transactivation through Its Acidic Glucose-Responsive Domains

The membrane-bound Nrf1 transcription factor regulates critical homeostatic and developmental genes. The conserved N-terminal homology box 1 (NHB1) sequence in Nrf1 targets the cap‘n’collar (CNC) basic basic-region leucine zipper (bZIP) factor to the endoplasmic reticulum (ER), but it is unknown how...

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Detalles Bibliográficos
Autores principales: Zhang, Yiguo, Ren, Yonggang, Li, Shaojun, Hayes, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973704/
https://www.ncbi.nlm.nih.gov/pubmed/24695487
http://dx.doi.org/10.1371/journal.pone.0093458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973704/
https://www.ncbi.nlm.nih.gov/pubmed/24695487
http://dx.doi.org/10.1371/journal.pone.0093458

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