ATP6V0C Knockdown in Neuroblastoma Cells Alters Autophagy-Lysosome Pathway Function and Metabolism of Proteins that Accumulate in Neurodegenerative Disease

ATP6V0C is the bafilomycin A1-binding subunit of vacuolar ATPase, an enzyme complex that critically regulates vesicular acidification. We and others have shown previously that bafilomycin A1 regulates cell viability, autophagic flux and metabolism of proteins that accumulate in neurodegenerative dis...

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Detalles Bibliográficos
Autores principales: Mangieri, Leandra R., Mader, Burton J., Thomas, Cailin E., Taylor, Charles A., Luker, Austin M., Tse, Tonia E., Huisingh, Carrie, Shacka, John J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973706/
https://www.ncbi.nlm.nih.gov/pubmed/24695574
http://dx.doi.org/10.1371/journal.pone.0093257

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