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Association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the Korean general population
BACKGROUND: The purpose of this study was to evaluate the association between blood manganese levels and the prevalence of chronic diseases in the Korean population. METHODS: This was a cross-sectional study based on the Korean National Health and Nutrition Examination Survey (KNAHNES). The study in...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973834/ https://www.ncbi.nlm.nih.gov/pubmed/24606630 http://dx.doi.org/10.1186/1472-6823-14-24 |
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author | Koh, Eun Sil Kim, Sung Jun Yoon, Hye Eun Chung, Jong Hee Chung, Sungjin Park, Cheol Whee Chang, Yoon Sik Shin, Seok Joon |
author_facet | Koh, Eun Sil Kim, Sung Jun Yoon, Hye Eun Chung, Jong Hee Chung, Sungjin Park, Cheol Whee Chang, Yoon Sik Shin, Seok Joon |
author_sort | Koh, Eun Sil |
collection | PubMed |
description | BACKGROUND: The purpose of this study was to evaluate the association between blood manganese levels and the prevalence of chronic diseases in the Korean population. METHODS: This was a cross-sectional study based on the Korean National Health and Nutrition Examination Survey (KNAHNES). The study included 3996 participants 20 years of age or older whose blood manganese levels had been measured. The participants were also evaluated for the presence of five chronic diseases: diabetes, renal dysfunction, hypertension, ischemic heart disease, and stroke. RESULTS: Blood manganese levels were significantly lower in the diabetes group compared with the non-diabetes group (1.26 ± 0.02 vs. 1.35 ± 0.01 μg/dL; p = 0.001) and the renal dysfunction group compared with those with normal renal function (1.28 ± 0.03 vs. 1.35 ± 0.01 μg/dL; p = 0.04). There was no significant association between blood manganese levels and the presence of ischemic heart disease or stroke. A multivariate logistic regression analysis adjusted for age, sex, and body mass index was performed; the odds ratio was 0.652 (95% CI: 0.46–0.92) for diabetes and 0.589 (95% CI: 0.39–0.88) for renal dysfunction when comparing the higher quartiles (Q2-4) with the lowest quartile (Q1) of blood manganese level. The prevalence of diabetes was 7.6% in Q1 and 5.3% in Q2-4 (p = 0.02). Similarly, the prevalence of renal dysfunction was 6.8% in Q1, compared with 4.6% in Q2-4 (p = 0.02). CONCLUSION: The prevalence of diabetes and renal dysfunction increased in participants with low blood manganese levels, suggesting that blood manganese may play a role in glucose homeostasis and renal function. |
format | Online Article Text |
id | pubmed-3973834 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-39738342014-04-04 Association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the Korean general population Koh, Eun Sil Kim, Sung Jun Yoon, Hye Eun Chung, Jong Hee Chung, Sungjin Park, Cheol Whee Chang, Yoon Sik Shin, Seok Joon BMC Endocr Disord Research Article BACKGROUND: The purpose of this study was to evaluate the association between blood manganese levels and the prevalence of chronic diseases in the Korean population. METHODS: This was a cross-sectional study based on the Korean National Health and Nutrition Examination Survey (KNAHNES). The study included 3996 participants 20 years of age or older whose blood manganese levels had been measured. The participants were also evaluated for the presence of five chronic diseases: diabetes, renal dysfunction, hypertension, ischemic heart disease, and stroke. RESULTS: Blood manganese levels were significantly lower in the diabetes group compared with the non-diabetes group (1.26 ± 0.02 vs. 1.35 ± 0.01 μg/dL; p = 0.001) and the renal dysfunction group compared with those with normal renal function (1.28 ± 0.03 vs. 1.35 ± 0.01 μg/dL; p = 0.04). There was no significant association between blood manganese levels and the presence of ischemic heart disease or stroke. A multivariate logistic regression analysis adjusted for age, sex, and body mass index was performed; the odds ratio was 0.652 (95% CI: 0.46–0.92) for diabetes and 0.589 (95% CI: 0.39–0.88) for renal dysfunction when comparing the higher quartiles (Q2-4) with the lowest quartile (Q1) of blood manganese level. The prevalence of diabetes was 7.6% in Q1 and 5.3% in Q2-4 (p = 0.02). Similarly, the prevalence of renal dysfunction was 6.8% in Q1, compared with 4.6% in Q2-4 (p = 0.02). CONCLUSION: The prevalence of diabetes and renal dysfunction increased in participants with low blood manganese levels, suggesting that blood manganese may play a role in glucose homeostasis and renal function. BioMed Central 2014-03-08 /pmc/articles/PMC3973834/ /pubmed/24606630 http://dx.doi.org/10.1186/1472-6823-14-24 Text en Copyright © 2014 Koh et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. |
spellingShingle | Research Article Koh, Eun Sil Kim, Sung Jun Yoon, Hye Eun Chung, Jong Hee Chung, Sungjin Park, Cheol Whee Chang, Yoon Sik Shin, Seok Joon Association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the Korean general population |
title | Association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the Korean general population |
title_full | Association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the Korean general population |
title_fullStr | Association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the Korean general population |
title_full_unstemmed | Association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the Korean general population |
title_short | Association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the Korean general population |
title_sort | association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the korean general population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973834/ https://www.ncbi.nlm.nih.gov/pubmed/24606630 http://dx.doi.org/10.1186/1472-6823-14-24 |
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