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Association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the Korean general population

BACKGROUND: The purpose of this study was to evaluate the association between blood manganese levels and the prevalence of chronic diseases in the Korean population. METHODS: This was a cross-sectional study based on the Korean National Health and Nutrition Examination Survey (KNAHNES). The study in...

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Autores principales: Koh, Eun Sil, Kim, Sung Jun, Yoon, Hye Eun, Chung, Jong Hee, Chung, Sungjin, Park, Cheol Whee, Chang, Yoon Sik, Shin, Seok Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973834/
https://www.ncbi.nlm.nih.gov/pubmed/24606630
http://dx.doi.org/10.1186/1472-6823-14-24
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author Koh, Eun Sil
Kim, Sung Jun
Yoon, Hye Eun
Chung, Jong Hee
Chung, Sungjin
Park, Cheol Whee
Chang, Yoon Sik
Shin, Seok Joon
author_facet Koh, Eun Sil
Kim, Sung Jun
Yoon, Hye Eun
Chung, Jong Hee
Chung, Sungjin
Park, Cheol Whee
Chang, Yoon Sik
Shin, Seok Joon
author_sort Koh, Eun Sil
collection PubMed
description BACKGROUND: The purpose of this study was to evaluate the association between blood manganese levels and the prevalence of chronic diseases in the Korean population. METHODS: This was a cross-sectional study based on the Korean National Health and Nutrition Examination Survey (KNAHNES). The study included 3996 participants 20 years of age or older whose blood manganese levels had been measured. The participants were also evaluated for the presence of five chronic diseases: diabetes, renal dysfunction, hypertension, ischemic heart disease, and stroke. RESULTS: Blood manganese levels were significantly lower in the diabetes group compared with the non-diabetes group (1.26 ± 0.02 vs. 1.35 ± 0.01 μg/dL; p = 0.001) and the renal dysfunction group compared with those with normal renal function (1.28 ± 0.03 vs. 1.35 ± 0.01 μg/dL; p = 0.04). There was no significant association between blood manganese levels and the presence of ischemic heart disease or stroke. A multivariate logistic regression analysis adjusted for age, sex, and body mass index was performed; the odds ratio was 0.652 (95% CI: 0.46–0.92) for diabetes and 0.589 (95% CI: 0.39–0.88) for renal dysfunction when comparing the higher quartiles (Q2-4) with the lowest quartile (Q1) of blood manganese level. The prevalence of diabetes was 7.6% in Q1 and 5.3% in Q2-4 (p = 0.02). Similarly, the prevalence of renal dysfunction was 6.8% in Q1, compared with 4.6% in Q2-4 (p = 0.02). CONCLUSION: The prevalence of diabetes and renal dysfunction increased in participants with low blood manganese levels, suggesting that blood manganese may play a role in glucose homeostasis and renal function.
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spelling pubmed-39738342014-04-04 Association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the Korean general population Koh, Eun Sil Kim, Sung Jun Yoon, Hye Eun Chung, Jong Hee Chung, Sungjin Park, Cheol Whee Chang, Yoon Sik Shin, Seok Joon BMC Endocr Disord Research Article BACKGROUND: The purpose of this study was to evaluate the association between blood manganese levels and the prevalence of chronic diseases in the Korean population. METHODS: This was a cross-sectional study based on the Korean National Health and Nutrition Examination Survey (KNAHNES). The study included 3996 participants 20 years of age or older whose blood manganese levels had been measured. The participants were also evaluated for the presence of five chronic diseases: diabetes, renal dysfunction, hypertension, ischemic heart disease, and stroke. RESULTS: Blood manganese levels were significantly lower in the diabetes group compared with the non-diabetes group (1.26 ± 0.02 vs. 1.35 ± 0.01 μg/dL; p = 0.001) and the renal dysfunction group compared with those with normal renal function (1.28 ± 0.03 vs. 1.35 ± 0.01 μg/dL; p = 0.04). There was no significant association between blood manganese levels and the presence of ischemic heart disease or stroke. A multivariate logistic regression analysis adjusted for age, sex, and body mass index was performed; the odds ratio was 0.652 (95% CI: 0.46–0.92) for diabetes and 0.589 (95% CI: 0.39–0.88) for renal dysfunction when comparing the higher quartiles (Q2-4) with the lowest quartile (Q1) of blood manganese level. The prevalence of diabetes was 7.6% in Q1 and 5.3% in Q2-4 (p = 0.02). Similarly, the prevalence of renal dysfunction was 6.8% in Q1, compared with 4.6% in Q2-4 (p = 0.02). CONCLUSION: The prevalence of diabetes and renal dysfunction increased in participants with low blood manganese levels, suggesting that blood manganese may play a role in glucose homeostasis and renal function. BioMed Central 2014-03-08 /pmc/articles/PMC3973834/ /pubmed/24606630 http://dx.doi.org/10.1186/1472-6823-14-24 Text en Copyright © 2014 Koh et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Research Article
Koh, Eun Sil
Kim, Sung Jun
Yoon, Hye Eun
Chung, Jong Hee
Chung, Sungjin
Park, Cheol Whee
Chang, Yoon Sik
Shin, Seok Joon
Association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the Korean general population
title Association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the Korean general population
title_full Association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the Korean general population
title_fullStr Association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the Korean general population
title_full_unstemmed Association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the Korean general population
title_short Association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the Korean general population
title_sort association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the korean general population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973834/
https://www.ncbi.nlm.nih.gov/pubmed/24606630
http://dx.doi.org/10.1186/1472-6823-14-24
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