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Association between anemia and falls in community-dwelling older people: cross-sectional results from the KORA-Age study
BACKGROUND: Falls and fractures are among the principal causes of disability, and mortality of older people. Therefore, identifying treatable risk factors for falls in this population is very important. Here we evaluate the association between anemia and falls in community-dwelling people aged 65 ye...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973957/ https://www.ncbi.nlm.nih.gov/pubmed/24602338 http://dx.doi.org/10.1186/1471-2318-14-29 |
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author | Thaler-Kall, Kathrin Döring, Angela Peters, Annette Thorand, Barbara Grill, Eva Koenig, Wolfgang Horsch, Alexander Meisinger, Christa |
author_facet | Thaler-Kall, Kathrin Döring, Angela Peters, Annette Thorand, Barbara Grill, Eva Koenig, Wolfgang Horsch, Alexander Meisinger, Christa |
author_sort | Thaler-Kall, Kathrin |
collection | PubMed |
description | BACKGROUND: Falls and fractures are among the principal causes of disability, and mortality of older people. Therefore, identifying treatable risk factors for falls in this population is very important. Here we evaluate the association between anemia and falls in community-dwelling people aged 65 years and older. METHODS: In 2009 967 community-dwelling people aged 65 years and older were included as part of the KORA-Age study. History of falls was assessed via questions derived from the National Health and Nutrition Examination Survey questionnaire. A non-fasting venous blood sample was obtained from all study participants. Anemia was defined as a hemoglobin level below 12 g/dL in women and below 13 g/dL in men according to the WHO criteria. Different logistic regression models were computed including relevant confounders such as sex, age, and disability to estimate Odds Ratios (OR) for falls. RESULTS: In the total sample there was no significant association between anemia and falls neither in the unadjusted (OR 1.35; 95% CI 0.87-2.09) nor in the multivariable-adjusted models (OR 1.06; 95% CI 0.66-1.70). The association between continuous hemoglobin levels and falls was significant in the unadjusted model (OR per 1 SD decrease 1.36; 95% CI 1.14-1.64), but after adjustment for age and sex the association was attenuated and lost its significance (OR 1.13; 95% CI 0.92-1.38). In age- and sex-stratified analyses, no significant associations between anemia or hemoglobin levels and falls could be found. However, in joint analysis in the total sample a significantly, more than two-fold increased risk was observed after multivariable adjustment in persons with anemia and disability (OR 2.10; 95% CI 1.12-3.93) in comparison to persons without anemia and disability. CONCLUSIONS: In the present study we have not found an independent association between hemoglobin levels or anemia and falls in older people from the general population. Because there was an additive effect of anemia and disability on the occurrence of falls, blood count should be measured in disabled older men and women to identify persons, who are at particular high risk for falls. |
format | Online Article Text |
id | pubmed-3973957 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-39739572014-04-04 Association between anemia and falls in community-dwelling older people: cross-sectional results from the KORA-Age study Thaler-Kall, Kathrin Döring, Angela Peters, Annette Thorand, Barbara Grill, Eva Koenig, Wolfgang Horsch, Alexander Meisinger, Christa BMC Geriatr Research Article BACKGROUND: Falls and fractures are among the principal causes of disability, and mortality of older people. Therefore, identifying treatable risk factors for falls in this population is very important. Here we evaluate the association between anemia and falls in community-dwelling people aged 65 years and older. METHODS: In 2009 967 community-dwelling people aged 65 years and older were included as part of the KORA-Age study. History of falls was assessed via questions derived from the National Health and Nutrition Examination Survey questionnaire. A non-fasting venous blood sample was obtained from all study participants. Anemia was defined as a hemoglobin level below 12 g/dL in women and below 13 g/dL in men according to the WHO criteria. Different logistic regression models were computed including relevant confounders such as sex, age, and disability to estimate Odds Ratios (OR) for falls. RESULTS: In the total sample there was no significant association between anemia and falls neither in the unadjusted (OR 1.35; 95% CI 0.87-2.09) nor in the multivariable-adjusted models (OR 1.06; 95% CI 0.66-1.70). The association between continuous hemoglobin levels and falls was significant in the unadjusted model (OR per 1 SD decrease 1.36; 95% CI 1.14-1.64), but after adjustment for age and sex the association was attenuated and lost its significance (OR 1.13; 95% CI 0.92-1.38). In age- and sex-stratified analyses, no significant associations between anemia or hemoglobin levels and falls could be found. However, in joint analysis in the total sample a significantly, more than two-fold increased risk was observed after multivariable adjustment in persons with anemia and disability (OR 2.10; 95% CI 1.12-3.93) in comparison to persons without anemia and disability. CONCLUSIONS: In the present study we have not found an independent association between hemoglobin levels or anemia and falls in older people from the general population. Because there was an additive effect of anemia and disability on the occurrence of falls, blood count should be measured in disabled older men and women to identify persons, who are at particular high risk for falls. BioMed Central 2014-03-07 /pmc/articles/PMC3973957/ /pubmed/24602338 http://dx.doi.org/10.1186/1471-2318-14-29 Text en Copyright © 2014 Thaler-Kall et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Thaler-Kall, Kathrin Döring, Angela Peters, Annette Thorand, Barbara Grill, Eva Koenig, Wolfgang Horsch, Alexander Meisinger, Christa Association between anemia and falls in community-dwelling older people: cross-sectional results from the KORA-Age study |
title | Association between anemia and falls in community-dwelling older people: cross-sectional results from the KORA-Age study |
title_full | Association between anemia and falls in community-dwelling older people: cross-sectional results from the KORA-Age study |
title_fullStr | Association between anemia and falls in community-dwelling older people: cross-sectional results from the KORA-Age study |
title_full_unstemmed | Association between anemia and falls in community-dwelling older people: cross-sectional results from the KORA-Age study |
title_short | Association between anemia and falls in community-dwelling older people: cross-sectional results from the KORA-Age study |
title_sort | association between anemia and falls in community-dwelling older people: cross-sectional results from the kora-age study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973957/ https://www.ncbi.nlm.nih.gov/pubmed/24602338 http://dx.doi.org/10.1186/1471-2318-14-29 |
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