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Epigenetic silencing of miR-375 induces trastuzumab resistance in HER2-positive breast cancer by targeting IGF1R

BACKGROUND: Resistance to humanized monoclonal erbB2/HER2 antibody, trastuzumab (Herceptin), has become a pivotal obstacle for targeted therapy of HER2-positive breast cancers. The activation of alternative growth factor receptors, in particular, the insulin-like growth factor 1 receptor (IGF1R), re...

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Detalles Bibliográficos
Autores principales:	Ye, Xing-Ming, Zhu, Hua-Yu, Bai, Wen-Dong, Wang, Ting, Wang, Lei, Chen, Ying, Yang, An-Gang, Jia, Lin-Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974046/ https://www.ncbi.nlm.nih.gov/pubmed/24571711 http://dx.doi.org/10.1186/1471-2407-14-134

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