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Cumulative ultraviolet radiation flux in adulthood and risk of incident skin cancers in women

BACKGROUND: Solar ultraviolet (UV) exposure estimated based on residential history has been used as a sun exposure indicator in previous case–control and descriptive studies. However, the associations of cumulative UV exposure based on residential history with different skin cancers, including melan...

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Autores principales: Wu, S, Han, J, Vleugels, R A, Puett, R, Laden, F, Hunter, D J, Qureshi, A A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974077/
https://www.ncbi.nlm.nih.gov/pubmed/24595003
http://dx.doi.org/10.1038/bjc.2014.43
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author Wu, S
Han, J
Vleugels, R A
Puett, R
Laden, F
Hunter, D J
Qureshi, A A
author_facet Wu, S
Han, J
Vleugels, R A
Puett, R
Laden, F
Hunter, D J
Qureshi, A A
author_sort Wu, S
collection PubMed
description BACKGROUND: Solar ultraviolet (UV) exposure estimated based on residential history has been used as a sun exposure indicator in previous case–control and descriptive studies. However, the associations of cumulative UV exposure based on residential history with different skin cancers, including melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC), have not been evaluated simultaneously in prospective studies. METHODS: We conducted a cohort study among 108 578 women in the Nurses' Health Study (1976–2006) to evaluate the relative risks of skin cancers with cumulative UV flux based on residential history in adulthood. RESULTS: Risk of SCC and BCC was significantly lower for women in lower quintiles vs the highest quintile of cumulative UV flux (both P for trend <0.0001). The association between cumulative UV flux and risk of melanoma did not reach statistical significance. However, risk of melanoma appeared to be lower among women in lower quintiles vs the highest quintile of cumulative UV flux in lag analyses with 2–10 years between exposure and outcome. The multivariable-adjusted hazard ratios per 200 × 10(−4) Robertson–Berger units increase in cumulative UV flux were 0.979 (95% confidence interval (CI): 0.933, 1.028) for melanoma, 1.072 (95% CI: 1.041, 1.103) for SCC, and 1.043 (95% CI: 1.034, 1.052) for BCC. CONCLUSIONS: Associations with cumulative UV exposure in adulthood among women differed for melanoma, SCC, and BCC, suggesting a potential variable role of UV radiation in adulthood in the carcinogenesis of the three major skin cancers.
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spelling pubmed-39740772015-04-01 Cumulative ultraviolet radiation flux in adulthood and risk of incident skin cancers in women Wu, S Han, J Vleugels, R A Puett, R Laden, F Hunter, D J Qureshi, A A Br J Cancer Epidemiology BACKGROUND: Solar ultraviolet (UV) exposure estimated based on residential history has been used as a sun exposure indicator in previous case–control and descriptive studies. However, the associations of cumulative UV exposure based on residential history with different skin cancers, including melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC), have not been evaluated simultaneously in prospective studies. METHODS: We conducted a cohort study among 108 578 women in the Nurses' Health Study (1976–2006) to evaluate the relative risks of skin cancers with cumulative UV flux based on residential history in adulthood. RESULTS: Risk of SCC and BCC was significantly lower for women in lower quintiles vs the highest quintile of cumulative UV flux (both P for trend <0.0001). The association between cumulative UV flux and risk of melanoma did not reach statistical significance. However, risk of melanoma appeared to be lower among women in lower quintiles vs the highest quintile of cumulative UV flux in lag analyses with 2–10 years between exposure and outcome. The multivariable-adjusted hazard ratios per 200 × 10(−4) Robertson–Berger units increase in cumulative UV flux were 0.979 (95% confidence interval (CI): 0.933, 1.028) for melanoma, 1.072 (95% CI: 1.041, 1.103) for SCC, and 1.043 (95% CI: 1.034, 1.052) for BCC. CONCLUSIONS: Associations with cumulative UV exposure in adulthood among women differed for melanoma, SCC, and BCC, suggesting a potential variable role of UV radiation in adulthood in the carcinogenesis of the three major skin cancers. Nature Publishing Group 2014-04-01 2014-03-04 /pmc/articles/PMC3974077/ /pubmed/24595003 http://dx.doi.org/10.1038/bjc.2014.43 Text en Copyright © 2014 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/3.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Epidemiology
Wu, S
Han, J
Vleugels, R A
Puett, R
Laden, F
Hunter, D J
Qureshi, A A
Cumulative ultraviolet radiation flux in adulthood and risk of incident skin cancers in women
title Cumulative ultraviolet radiation flux in adulthood and risk of incident skin cancers in women
title_full Cumulative ultraviolet radiation flux in adulthood and risk of incident skin cancers in women
title_fullStr Cumulative ultraviolet radiation flux in adulthood and risk of incident skin cancers in women
title_full_unstemmed Cumulative ultraviolet radiation flux in adulthood and risk of incident skin cancers in women
title_short Cumulative ultraviolet radiation flux in adulthood and risk of incident skin cancers in women
title_sort cumulative ultraviolet radiation flux in adulthood and risk of incident skin cancers in women
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974077/
https://www.ncbi.nlm.nih.gov/pubmed/24595003
http://dx.doi.org/10.1038/bjc.2014.43
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