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Synaptotagmin 1 and Ca(2+) drive trans SNARE zippering

Synaptotagmin 1 (Syt1) is a major Ca(2+)-sensor that evokes neurotransmitter release. Here we used site-specific fluorescence resonance energy transfer (FRET) assay to investigate the effects of Syt1 on SNAREpin assembly. C2AB, a soluble version of Syt1, had virtually no stimulatory effect on the ra...

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Detalles Bibliográficos
Autores principales:	Lai, Ying, Lou, Xiaochu, Wang, Chuqi, Xia, Tian, Tong, Jiansong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974132/ https://www.ncbi.nlm.nih.gov/pubmed/24694579 http://dx.doi.org/10.1038/srep04575

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