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ATP and potassium ions: a deadly combination for astrocytes

The ATP release channel Pannexin1 (Panx1) is self-regulated, i.e. the permeant ATP inhibits the channel from the extracellular space. The affinity of the ATP binding site is lower than that of the purinergic P2X(7) receptor allowing a transient activation of Panx1 by ATP through P2X(7)R. Here we sho...

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Detalles Bibliográficos
Autores principales:	Jackson, David G., Wang, Junjie, Keane, Robert W., Scemes, Eliana, Dahl, Gerhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974143/ https://www.ncbi.nlm.nih.gov/pubmed/24694658 http://dx.doi.org/10.1038/srep04576

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