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Epigenetic plasticity of Cd8a locus during CD8(+) T-cell development and effector differentiation and reprogramming

Modulation of CD8 coreceptor levels can profoundly affect T-cell sensitivity to antigen. Here we show that the heritable downregulation of CD8 during type 2 polarization of murine CD8(+) effector T cells in vitro and in vivo is associated with CpG methylation of several regions of the Cd8a locus. Th...

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Detalles Bibliográficos
Autores principales:	Harland, Kim L., Day, E. Bridie, Apte, Simon H., Russ, Brendan E., Doherty, Peter C., Turner, Stephen J., Kelso, Anne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974221/ https://www.ncbi.nlm.nih.gov/pubmed/24675400 http://dx.doi.org/10.1038/ncomms4547

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