Propionylcarnitine and methionine concentrations in newborns with hypospadias

INTRODUCTION: Of interest is if factors like maternal diet can influence the risk of hypospadias–affected pregnancy. Increased propionylcarnitine (C3) is regarded as a biomarker of vitamin B12 deficiency. The retrospective study was undertaken to determine whether increased propionylcarnitine and lo...

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Detalles Bibliográficos
Autores principales: Kowal, Andrzej, Mydlak, Dariusz, Ołtarzewski, Mariusz, Bauer, Anna, Sawicka, Ewa, Hozyasz, Kamil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Polish Urological Association 2013
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974481/
https://www.ncbi.nlm.nih.gov/pubmed/24707392
http://dx.doi.org/10.5173/ceju.2013.03.art36
Descripción
Sumario:INTRODUCTION: Of interest is if factors like maternal diet can influence the risk of hypospadias–affected pregnancy. Increased propionylcarnitine (C3) is regarded as a biomarker of vitamin B12 deficiency. The retrospective study was undertaken to determine whether increased propionylcarnitine and low methionine in newborns are associated with hypospadias. MATERIAL AND METHODS: 41 newborns with hypospadias and 90 control newborns without congenital anomalies were investigated. Whole blood propionylcarnitine and methionine concentrations were measured using tandem mass spectrometry. RESULTS: The mean concentration of propionylcarnitine was higher in newborns with hypospadias compared with newborns without congenital anomalies (p = 0.026). The mean methionine level in cases was insignificantly lower than in controls. CONCLUSION: There appears to be an association between decreased vitamin B12, as indexed by an increase of propionylcarnitine, and hypospadias in the investigated group of patients.

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