Kinase domain mutations confer resistance to novel inhibitors targeting JAK2V617F in myeloproliferative neoplasms

The transforming JAK2V617F kinase is frequently associated with myeloproliferative neoplasms (MPNs) and thought to be instrumental for the overproduction of myeloid lineage cells. Several small molecule drugs targeting JAK2 are currently in clinical development for treatment in these diseases. We pe...

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Detalles Bibliográficos
Autores principales: Deshpande, Anagha, Reddy, Mamatha M., Schade, Georg O.M., Ray, Arghya, Chowdary, Tirumala K., Griffin, James D., Sattler, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974504/
https://www.ncbi.nlm.nih.gov/pubmed/21926964
http://dx.doi.org/10.1038/leu.2011.255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974504/
https://www.ncbi.nlm.nih.gov/pubmed/21926964
http://dx.doi.org/10.1038/leu.2011.255

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