A Central Role for GRB10 in Regulation of Islet Function in Man

Variants in the growth factor receptor-bound protein 10 (GRB10) gene were in a GWAS meta-analysis associated with reduced glucose-stimulated insulin secretion and increased risk of type 2 diabetes (T2D) if inherited from the father, but inexplicably reduced fasting glucose when inherited from the mo...

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Detalles Bibliográficos
Autores principales: Prokopenko, Inga, Poon, Wenny, Mägi, Reedik, Prasad B, Rashmi, Salehi, S. Albert, Almgren, Peter, Osmark, Peter, Bouatia-Naji, Nabila, Wierup, Nils, Fall, Tove, Stančáková, Alena, Barker, Adam, Lagou, Vasiliki, Osmond, Clive, Xie, Weijia, Lahti, Jari, Jackson, Anne U., Cheng, Yu-Ching, Liu, Jie, O'Connell, Jeffrey R., Blomstedt, Paul A., Fadista, Joao, Alkayyali, Sami, Dayeh, Tasnim, Ahlqvist, Emma, Taneera, Jalal, Lecoeur, Cecile, Kumar, Ashish, Hansson, Ola, Hansson, Karin, Voight, Benjamin F., Kang, Hyun Min, Levy-Marchal, Claire, Vatin, Vincent, Palotie, Aarno, Syvänen, Ann-Christine, Mari, Andrea, Weedon, Michael N., Loos, Ruth J. F., Ong, Ken K., Nilsson, Peter, Isomaa, Bo, Tuomi, Tiinamaija, Wareham, Nicholas J., Stumvoll, Michael, Widen, Elisabeth, Lakka, Timo A., Langenberg, Claudia, Tönjes, Anke, Rauramaa, Rainer, Kuusisto, Johanna, Frayling, Timothy M., Froguel, Philippe, Walker, Mark, Eriksson, Johan G., Ling, Charlotte, Kovacs, Peter, Ingelsson, Erik, McCarthy, Mark I., Shuldiner, Alan R., Silver, Kristi D., Laakso, Markku, Groop, Leif, Lyssenko, Valeriya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974640/
https://www.ncbi.nlm.nih.gov/pubmed/24699409
http://dx.doi.org/10.1371/journal.pgen.1004235

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