Temporary Treatment during Primary HIV Infection Does Not Affect Virologic Response to Subsequent Long-Term Treatment

Temporary cART during primary HIV-infection (PHI) did not select for drug resistance mutations after treatment interruption and did not affect the subsequent virological response to long-term cART. Our data demonstrate that fear of drug resistance development is not a valid argument to refrain from...

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Autores principales: Grijsen, Marlous L., Wit, Ferdinand W. N. M., Jurriaans, Suzanne, Kroon, Frank P., Schippers, Emile F., Koopmans, Peter, Gras, Luuk, Lange, Joep M. A., Prins, Jan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974663/
https://www.ncbi.nlm.nih.gov/pubmed/24699072
http://dx.doi.org/10.1371/journal.pone.0089639
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author Grijsen, Marlous L.
Wit, Ferdinand W. N. M.
Jurriaans, Suzanne
Kroon, Frank P.
Schippers, Emile F.
Koopmans, Peter
Gras, Luuk
Lange, Joep M. A.
Prins, Jan M.
author_facet Grijsen, Marlous L.
Wit, Ferdinand W. N. M.
Jurriaans, Suzanne
Kroon, Frank P.
Schippers, Emile F.
Koopmans, Peter
Gras, Luuk
Lange, Joep M. A.
Prins, Jan M.
author_sort Grijsen, Marlous L.
collection PubMed
description Temporary cART during primary HIV-infection (PHI) did not select for drug resistance mutations after treatment interruption and did not affect the subsequent virological response to long-term cART. Our data demonstrate that fear of drug resistance development is not a valid argument to refrain from temporary early treatment during PHI.
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spelling pubmed-39746632014-04-08 Temporary Treatment during Primary HIV Infection Does Not Affect Virologic Response to Subsequent Long-Term Treatment Grijsen, Marlous L. Wit, Ferdinand W. N. M. Jurriaans, Suzanne Kroon, Frank P. Schippers, Emile F. Koopmans, Peter Gras, Luuk Lange, Joep M. A. Prins, Jan M. PLoS One Research Article Temporary cART during primary HIV-infection (PHI) did not select for drug resistance mutations after treatment interruption and did not affect the subsequent virological response to long-term cART. Our data demonstrate that fear of drug resistance development is not a valid argument to refrain from temporary early treatment during PHI. Public Library of Science 2014-04-03 /pmc/articles/PMC3974663/ /pubmed/24699072 http://dx.doi.org/10.1371/journal.pone.0089639 Text en © 2014 Grijsen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Grijsen, Marlous L.
Wit, Ferdinand W. N. M.
Jurriaans, Suzanne
Kroon, Frank P.
Schippers, Emile F.
Koopmans, Peter
Gras, Luuk
Lange, Joep M. A.
Prins, Jan M.
Temporary Treatment during Primary HIV Infection Does Not Affect Virologic Response to Subsequent Long-Term Treatment
title Temporary Treatment during Primary HIV Infection Does Not Affect Virologic Response to Subsequent Long-Term Treatment
title_full Temporary Treatment during Primary HIV Infection Does Not Affect Virologic Response to Subsequent Long-Term Treatment
title_fullStr Temporary Treatment during Primary HIV Infection Does Not Affect Virologic Response to Subsequent Long-Term Treatment
title_full_unstemmed Temporary Treatment during Primary HIV Infection Does Not Affect Virologic Response to Subsequent Long-Term Treatment
title_short Temporary Treatment during Primary HIV Infection Does Not Affect Virologic Response to Subsequent Long-Term Treatment
title_sort temporary treatment during primary hiv infection does not affect virologic response to subsequent long-term treatment
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974663/
https://www.ncbi.nlm.nih.gov/pubmed/24699072
http://dx.doi.org/10.1371/journal.pone.0089639
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