Cargando…

Prediction and prevention of the first psychotic episode: new directions and opportunities

In the last few decades, substantial research has focused on the possibility of early detection and prevention of the first psychotic episode in young individuals at risk of developing this mental disturbance; however, unresolved clinical and ethical issues still call for further investigations. New...

Descripción completa

Detalles Bibliográficos
Autores principales: Piras, Sara, Casu, Gianluca, Casu, Maria Antonietta, Orrù, Alessandro, Ruiu, Stefania, Pilleri, Antonio, Manca, Gabriella, Marchese, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974689/
https://www.ncbi.nlm.nih.gov/pubmed/24729711
http://dx.doi.org/10.2147/TCRM.S55770
_version_ 1782479500415598592
author Piras, Sara
Casu, Gianluca
Casu, Maria Antonietta
Orrù, Alessandro
Ruiu, Stefania
Pilleri, Antonio
Manca, Gabriella
Marchese, Giorgio
author_facet Piras, Sara
Casu, Gianluca
Casu, Maria Antonietta
Orrù, Alessandro
Ruiu, Stefania
Pilleri, Antonio
Manca, Gabriella
Marchese, Giorgio
author_sort Piras, Sara
collection PubMed
description In the last few decades, substantial research has focused on the possibility of early detection and prevention of the first psychotic episode in young individuals at risk of developing this mental disturbance; however, unresolved clinical and ethical issues still call for further investigations. New perspectives and opportunities may come from the identification of selective psychopathological and instrumental markers linking the appearance of subtle psychotic symptoms with the clinical outcome of specific mental pathologies. Furthermore, empirically derived algorithms and risk staging models should facilitate the identification of targeted prevention therapies, possibly improving the efficacy of well-tolerated therapeutic approaches, such as psychological interventions and natural compound supplementations. To date, the collected evidence on the efficacy and tolerability of pharmacological prevention therapies raises more doubts than hopes. A very early detection of risk and appropriate symptomatic pattern classifications may provide a chance to better match prevention strategies with the development of psychosis.
format Online
Article
Text
id pubmed-3974689
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-39746892014-04-11 Prediction and prevention of the first psychotic episode: new directions and opportunities Piras, Sara Casu, Gianluca Casu, Maria Antonietta Orrù, Alessandro Ruiu, Stefania Pilleri, Antonio Manca, Gabriella Marchese, Giorgio Ther Clin Risk Manag Review In the last few decades, substantial research has focused on the possibility of early detection and prevention of the first psychotic episode in young individuals at risk of developing this mental disturbance; however, unresolved clinical and ethical issues still call for further investigations. New perspectives and opportunities may come from the identification of selective psychopathological and instrumental markers linking the appearance of subtle psychotic symptoms with the clinical outcome of specific mental pathologies. Furthermore, empirically derived algorithms and risk staging models should facilitate the identification of targeted prevention therapies, possibly improving the efficacy of well-tolerated therapeutic approaches, such as psychological interventions and natural compound supplementations. To date, the collected evidence on the efficacy and tolerability of pharmacological prevention therapies raises more doubts than hopes. A very early detection of risk and appropriate symptomatic pattern classifications may provide a chance to better match prevention strategies with the development of psychosis. Dove Medical Press 2014-03-28 /pmc/articles/PMC3974689/ /pubmed/24729711 http://dx.doi.org/10.2147/TCRM.S55770 Text en © 2014 Piras et al. This work is published by Dove Medical Press Ltd, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Ltd, provided the work is properly attributed.
spellingShingle Review
Piras, Sara
Casu, Gianluca
Casu, Maria Antonietta
Orrù, Alessandro
Ruiu, Stefania
Pilleri, Antonio
Manca, Gabriella
Marchese, Giorgio
Prediction and prevention of the first psychotic episode: new directions and opportunities
title Prediction and prevention of the first psychotic episode: new directions and opportunities
title_full Prediction and prevention of the first psychotic episode: new directions and opportunities
title_fullStr Prediction and prevention of the first psychotic episode: new directions and opportunities
title_full_unstemmed Prediction and prevention of the first psychotic episode: new directions and opportunities
title_short Prediction and prevention of the first psychotic episode: new directions and opportunities
title_sort prediction and prevention of the first psychotic episode: new directions and opportunities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974689/
https://www.ncbi.nlm.nih.gov/pubmed/24729711
http://dx.doi.org/10.2147/TCRM.S55770
work_keys_str_mv AT pirassara predictionandpreventionofthefirstpsychoticepisodenewdirectionsandopportunities
AT casugianluca predictionandpreventionofthefirstpsychoticepisodenewdirectionsandopportunities
AT casumariaantonietta predictionandpreventionofthefirstpsychoticepisodenewdirectionsandopportunities
AT orrualessandro predictionandpreventionofthefirstpsychoticepisodenewdirectionsandopportunities
AT ruiustefania predictionandpreventionofthefirstpsychoticepisodenewdirectionsandopportunities
AT pilleriantonio predictionandpreventionofthefirstpsychoticepisodenewdirectionsandopportunities
AT mancagabriella predictionandpreventionofthefirstpsychoticepisodenewdirectionsandopportunities
AT marchesegiorgio predictionandpreventionofthefirstpsychoticepisodenewdirectionsandopportunities