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A Novel Fibrosis Index Comprising a Non-Cholesterol Sterol Accurately Predicts HCV-Related Liver Cirrhosis

Diagnosis of liver cirrhosis is essential in the management of chronic hepatitis C virus (HCV) infection. Liver biopsy is invasive and thus entails a risk of complications as well as a potential risk of sampling error. Therefore, non-invasive diagnostic tools are preferential. The aim of the present...

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Autores principales: Ydreborg, Magdalena, Lisovskaja, Vera, Lagging, Martin, Brehm Christensen, Peer, Langeland, Nina, Buhl, Mads Rauning, Pedersen, Court, Mørch, Kristine, Wejstål, Rune, Norkrans, Gunnar, Lindh, Magnus, Färkkilä, Martti, Westin, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974766/
https://www.ncbi.nlm.nih.gov/pubmed/24699777
http://dx.doi.org/10.1371/journal.pone.0093601
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author Ydreborg, Magdalena
Lisovskaja, Vera
Lagging, Martin
Brehm Christensen, Peer
Langeland, Nina
Buhl, Mads Rauning
Pedersen, Court
Mørch, Kristine
Wejstål, Rune
Norkrans, Gunnar
Lindh, Magnus
Färkkilä, Martti
Westin, Johan
author_facet Ydreborg, Magdalena
Lisovskaja, Vera
Lagging, Martin
Brehm Christensen, Peer
Langeland, Nina
Buhl, Mads Rauning
Pedersen, Court
Mørch, Kristine
Wejstål, Rune
Norkrans, Gunnar
Lindh, Magnus
Färkkilä, Martti
Westin, Johan
author_sort Ydreborg, Magdalena
collection PubMed
description Diagnosis of liver cirrhosis is essential in the management of chronic hepatitis C virus (HCV) infection. Liver biopsy is invasive and thus entails a risk of complications as well as a potential risk of sampling error. Therefore, non-invasive diagnostic tools are preferential. The aim of the present study was to create a model for accurate prediction of liver cirrhosis based on patient characteristics and biomarkers of liver fibrosis, including a panel of non-cholesterol sterols reflecting cholesterol synthesis and absorption and secretion. We evaluated variables with potential predictive significance for liver fibrosis in 278 patients originally included in a multicenter phase III treatment trial for chronic HCV infection. A stepwise multivariate logistic model selection was performed with liver cirrhosis, defined as Ishak fibrosis stage 5–6, as the outcome variable. A new index, referred to as Nordic Liver Index (NoLI) in the paper, was based on the model: Log-odds (predicting cirrhosis) = −12.17+ (age×0.11) + (BMI (kg/m(2))×0.23) + (D(7)-lathosterol (μg/100 mg cholesterol)×(−0.013)) + (Platelet count (x10(9)/L)×(−0.018)) + (Prothrombin-INR×3.69). The area under the ROC curve (AUROC) for prediction of cirrhosis was 0.91 (95% CI 0.86–0.96). The index was validated in a separate cohort of 83 patients and the AUROC for this cohort was similar (0.90; 95% CI: 0.82–0.98). In conclusion, the new index may complement other methods in diagnosing cirrhosis in patients with chronic HCV infection.
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spelling pubmed-39747662014-04-08 A Novel Fibrosis Index Comprising a Non-Cholesterol Sterol Accurately Predicts HCV-Related Liver Cirrhosis Ydreborg, Magdalena Lisovskaja, Vera Lagging, Martin Brehm Christensen, Peer Langeland, Nina Buhl, Mads Rauning Pedersen, Court Mørch, Kristine Wejstål, Rune Norkrans, Gunnar Lindh, Magnus Färkkilä, Martti Westin, Johan PLoS One Research Article Diagnosis of liver cirrhosis is essential in the management of chronic hepatitis C virus (HCV) infection. Liver biopsy is invasive and thus entails a risk of complications as well as a potential risk of sampling error. Therefore, non-invasive diagnostic tools are preferential. The aim of the present study was to create a model for accurate prediction of liver cirrhosis based on patient characteristics and biomarkers of liver fibrosis, including a panel of non-cholesterol sterols reflecting cholesterol synthesis and absorption and secretion. We evaluated variables with potential predictive significance for liver fibrosis in 278 patients originally included in a multicenter phase III treatment trial for chronic HCV infection. A stepwise multivariate logistic model selection was performed with liver cirrhosis, defined as Ishak fibrosis stage 5–6, as the outcome variable. A new index, referred to as Nordic Liver Index (NoLI) in the paper, was based on the model: Log-odds (predicting cirrhosis) = −12.17+ (age×0.11) + (BMI (kg/m(2))×0.23) + (D(7)-lathosterol (μg/100 mg cholesterol)×(−0.013)) + (Platelet count (x10(9)/L)×(−0.018)) + (Prothrombin-INR×3.69). The area under the ROC curve (AUROC) for prediction of cirrhosis was 0.91 (95% CI 0.86–0.96). The index was validated in a separate cohort of 83 patients and the AUROC for this cohort was similar (0.90; 95% CI: 0.82–0.98). In conclusion, the new index may complement other methods in diagnosing cirrhosis in patients with chronic HCV infection. Public Library of Science 2014-04-03 /pmc/articles/PMC3974766/ /pubmed/24699777 http://dx.doi.org/10.1371/journal.pone.0093601 Text en © 2014 Ydreborg et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Ydreborg, Magdalena
Lisovskaja, Vera
Lagging, Martin
Brehm Christensen, Peer
Langeland, Nina
Buhl, Mads Rauning
Pedersen, Court
Mørch, Kristine
Wejstål, Rune
Norkrans, Gunnar
Lindh, Magnus
Färkkilä, Martti
Westin, Johan
A Novel Fibrosis Index Comprising a Non-Cholesterol Sterol Accurately Predicts HCV-Related Liver Cirrhosis
title A Novel Fibrosis Index Comprising a Non-Cholesterol Sterol Accurately Predicts HCV-Related Liver Cirrhosis
title_full A Novel Fibrosis Index Comprising a Non-Cholesterol Sterol Accurately Predicts HCV-Related Liver Cirrhosis
title_fullStr A Novel Fibrosis Index Comprising a Non-Cholesterol Sterol Accurately Predicts HCV-Related Liver Cirrhosis
title_full_unstemmed A Novel Fibrosis Index Comprising a Non-Cholesterol Sterol Accurately Predicts HCV-Related Liver Cirrhosis
title_short A Novel Fibrosis Index Comprising a Non-Cholesterol Sterol Accurately Predicts HCV-Related Liver Cirrhosis
title_sort novel fibrosis index comprising a non-cholesterol sterol accurately predicts hcv-related liver cirrhosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974766/
https://www.ncbi.nlm.nih.gov/pubmed/24699777
http://dx.doi.org/10.1371/journal.pone.0093601
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