In Vitro Evaluation of the Inhibitory Potential of Pharmaceutical Excipients on Human Carboxylesterase 1A and 2

Two major forms of human carboxylesterase (CES), CES1A and CES2, dominate the pharmacokinetics of most prodrugs such as imidapril and irinotecan (CPT-11). Excipients, largely used as insert vehicles in formulation, have been recently reported to affect drug enzyme activity. The influence of excipien...

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Detalles Bibliográficos
Autores principales: Zhang, Chengliang, Xu, Yanjiao, Zhong, Qiaoni, Li, Xiping, Gao, Ping, Feng, Chengyang, Chu, Qian, Chen, Yuan, Liu, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974814/
https://www.ncbi.nlm.nih.gov/pubmed/24699684
http://dx.doi.org/10.1371/journal.pone.0093819

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