Genetic Variability of Plasmodium malariae dihydropteroate synthase (dhps) in Four Asian Countries

The dihydropteroate synthase (dhps) genes of 44 P. malariae strains from four Asian countries were isolated. Only a limited number of polymorphisms were observed. Comparison with homologous mutations in other Plasmodium species showed that these polymorphisms are unlikely to be associated with sulfa...

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Detalles Bibliográficos
Autores principales: Tanomsing, Naowarat, Mayxay, Mayfong, Newton, Paul N., Nosten, Francois, Dolecek, Christiane, Hien, Tran Tinh, White, Nicholas J., Day, Nicholas P. J., Dondorp, Arjen M., Imwong, Mallika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974843/
https://www.ncbi.nlm.nih.gov/pubmed/24699454
http://dx.doi.org/10.1371/journal.pone.0093942
Descripción
Sumario:The dihydropteroate synthase (dhps) genes of 44 P. malariae strains from four Asian countries were isolated. Only a limited number of polymorphisms were observed. Comparison with homologous mutations in other Plasmodium species showed that these polymorphisms are unlikely to be associated with sulfadoxine resistance.

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