Genetic Variability of Plasmodium malariae dihydropteroate synthase (dhps) in Four Asian Countries

The dihydropteroate synthase (dhps) genes of 44 P. malariae strains from four Asian countries were isolated. Only a limited number of polymorphisms were observed. Comparison with homologous mutations in other Plasmodium species showed that these polymorphisms are unlikely to be associated with sulfa...

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Autores principales: Tanomsing, Naowarat, Mayxay, Mayfong, Newton, Paul N., Nosten, Francois, Dolecek, Christiane, Hien, Tran Tinh, White, Nicholas J., Day, Nicholas P. J., Dondorp, Arjen M., Imwong, Mallika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974843/
https://www.ncbi.nlm.nih.gov/pubmed/24699454
http://dx.doi.org/10.1371/journal.pone.0093942
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author Tanomsing, Naowarat
Mayxay, Mayfong
Newton, Paul N.
Nosten, Francois
Dolecek, Christiane
Hien, Tran Tinh
White, Nicholas J.
Day, Nicholas P. J.
Dondorp, Arjen M.
Imwong, Mallika
author_facet Tanomsing, Naowarat
Mayxay, Mayfong
Newton, Paul N.
Nosten, Francois
Dolecek, Christiane
Hien, Tran Tinh
White, Nicholas J.
Day, Nicholas P. J.
Dondorp, Arjen M.
Imwong, Mallika
author_sort Tanomsing, Naowarat
collection PubMed
description The dihydropteroate synthase (dhps) genes of 44 P. malariae strains from four Asian countries were isolated. Only a limited number of polymorphisms were observed. Comparison with homologous mutations in other Plasmodium species showed that these polymorphisms are unlikely to be associated with sulfadoxine resistance.
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spelling pubmed-39748432014-04-08 Genetic Variability of Plasmodium malariae dihydropteroate synthase (dhps) in Four Asian Countries Tanomsing, Naowarat Mayxay, Mayfong Newton, Paul N. Nosten, Francois Dolecek, Christiane Hien, Tran Tinh White, Nicholas J. Day, Nicholas P. J. Dondorp, Arjen M. Imwong, Mallika PLoS One Research Article The dihydropteroate synthase (dhps) genes of 44 P. malariae strains from four Asian countries were isolated. Only a limited number of polymorphisms were observed. Comparison with homologous mutations in other Plasmodium species showed that these polymorphisms are unlikely to be associated with sulfadoxine resistance. Public Library of Science 2014-04-03 /pmc/articles/PMC3974843/ /pubmed/24699454 http://dx.doi.org/10.1371/journal.pone.0093942 Text en © 2014 Tanomsing et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Tanomsing, Naowarat
Mayxay, Mayfong
Newton, Paul N.
Nosten, Francois
Dolecek, Christiane
Hien, Tran Tinh
White, Nicholas J.
Day, Nicholas P. J.
Dondorp, Arjen M.
Imwong, Mallika
Genetic Variability of Plasmodium malariae dihydropteroate synthase (dhps) in Four Asian Countries
title Genetic Variability of Plasmodium malariae dihydropteroate synthase (dhps) in Four Asian Countries
title_full Genetic Variability of Plasmodium malariae dihydropteroate synthase (dhps) in Four Asian Countries
title_fullStr Genetic Variability of Plasmodium malariae dihydropteroate synthase (dhps) in Four Asian Countries
title_full_unstemmed Genetic Variability of Plasmodium malariae dihydropteroate synthase (dhps) in Four Asian Countries
title_short Genetic Variability of Plasmodium malariae dihydropteroate synthase (dhps) in Four Asian Countries
title_sort genetic variability of plasmodium malariae dihydropteroate synthase (dhps) in four asian countries
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974843/
https://www.ncbi.nlm.nih.gov/pubmed/24699454
http://dx.doi.org/10.1371/journal.pone.0093942
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