Efficient Parvovirus Replication Requires CRL4(Cdt2)-Targeted Depletion of p21 to Prevent Its Inhibitory Interaction with PCNA

Infection by the autonomous parvovirus minute virus of mice (MVM) induces a vigorous DNA damage response in host cells which it utilizes for its efficient replication. Although p53 remains activated, p21 protein levels remain low throughout the course of infection. We show here that efficient MVM re...

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Detalles Bibliográficos
Autores principales: Adeyemi, Richard O., Fuller, Matthew S., Pintel, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974872/
https://www.ncbi.nlm.nih.gov/pubmed/24699724
http://dx.doi.org/10.1371/journal.ppat.1004055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974872/
https://www.ncbi.nlm.nih.gov/pubmed/24699724
http://dx.doi.org/10.1371/journal.ppat.1004055

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