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Primary mediastinal large B-cell lymphoma: a single-center experience in Korea

BACKGROUND: Primary mediastinal large B-cell lymphoma (PMBL) is a distinct subtype of non-Hodgkin lymphoma, which has no consensus for its ideal treatment or prognosis. METHODS: We reviewed the clinicopathologic features and clinical outcomes of 25 PMBL cases diagnosed at a single institution betwee...

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Autores principales: Ahn, Heui June, Yoon, Dok-Hyun, Kim, Shin, Lee, Kyoungmin, Kang, EunHee, Huh, Jooryung, Park, Chan-Sik, Suh, Cheolwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974955/
https://www.ncbi.nlm.nih.gov/pubmed/24724065
http://dx.doi.org/10.5045/br.2014.49.1.36
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author Ahn, Heui June
Yoon, Dok-Hyun
Kim, Shin
Lee, Kyoungmin
Kang, EunHee
Huh, Jooryung
Park, Chan-Sik
Suh, Cheolwon
author_facet Ahn, Heui June
Yoon, Dok-Hyun
Kim, Shin
Lee, Kyoungmin
Kang, EunHee
Huh, Jooryung
Park, Chan-Sik
Suh, Cheolwon
author_sort Ahn, Heui June
collection PubMed
description BACKGROUND: Primary mediastinal large B-cell lymphoma (PMBL) is a distinct subtype of non-Hodgkin lymphoma, which has no consensus for its ideal treatment or prognosis. METHODS: We reviewed the clinicopathologic features and clinical outcomes of 25 PMBL cases diagnosed at a single institution between 1993 and 2009 and compared them with 588 cases of non-mediastinal, diffuse large B-cell lymphoma (DLBCL, control group) diagnosed during the same period. RESULTS: Thirteen (52.0%) PMBL patients had Ann Arbor stage III or IV disease, and 10 (40.0%) had B symptoms. Thirteen (52%) PMBL patients were classified as high-intermediate/high-risk according to the International Prognostic Index. There was a significant prevalence of young (median: 31 years; range, 15-78 years; P<0.001), female (68%; P=0.014) patients in the PMBL group compared to the control group (median: 56 years; range, 15-85 years; 43.2% female). Bulky disease and elevated levels of lactate dehydrogenase (LDH) were more frequent in the PMBL group (P<0.001 and P=0.003, respectively). Nineteen (76%) PBML patients achieved complete remission, and 18 were alive at the last follow-up (median: 43 months; range, 1-92 months). There was no difference in the 3-year, overall survival rate (72%, 95% confidence interval [CI]: 54.0-83.0 versus 70.1%, 95% CI, 109.0-126.0; P=0.686) between PMBL and control patients, respectively. CONCLUSION: Compared to patients with non-mediastinal DLBCL, Korean patients with PMBL are predominantly young women with bulky disease and high LDH levels but with no significant difference in survival.
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spelling pubmed-39749552014-04-10 Primary mediastinal large B-cell lymphoma: a single-center experience in Korea Ahn, Heui June Yoon, Dok-Hyun Kim, Shin Lee, Kyoungmin Kang, EunHee Huh, Jooryung Park, Chan-Sik Suh, Cheolwon Blood Res Original Article BACKGROUND: Primary mediastinal large B-cell lymphoma (PMBL) is a distinct subtype of non-Hodgkin lymphoma, which has no consensus for its ideal treatment or prognosis. METHODS: We reviewed the clinicopathologic features and clinical outcomes of 25 PMBL cases diagnosed at a single institution between 1993 and 2009 and compared them with 588 cases of non-mediastinal, diffuse large B-cell lymphoma (DLBCL, control group) diagnosed during the same period. RESULTS: Thirteen (52.0%) PMBL patients had Ann Arbor stage III or IV disease, and 10 (40.0%) had B symptoms. Thirteen (52%) PMBL patients were classified as high-intermediate/high-risk according to the International Prognostic Index. There was a significant prevalence of young (median: 31 years; range, 15-78 years; P<0.001), female (68%; P=0.014) patients in the PMBL group compared to the control group (median: 56 years; range, 15-85 years; 43.2% female). Bulky disease and elevated levels of lactate dehydrogenase (LDH) were more frequent in the PMBL group (P<0.001 and P=0.003, respectively). Nineteen (76%) PBML patients achieved complete remission, and 18 were alive at the last follow-up (median: 43 months; range, 1-92 months). There was no difference in the 3-year, overall survival rate (72%, 95% confidence interval [CI]: 54.0-83.0 versus 70.1%, 95% CI, 109.0-126.0; P=0.686) between PMBL and control patients, respectively. CONCLUSION: Compared to patients with non-mediastinal DLBCL, Korean patients with PMBL are predominantly young women with bulky disease and high LDH levels but with no significant difference in survival. Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis 2014-03 2014-03-24 /pmc/articles/PMC3974955/ /pubmed/24724065 http://dx.doi.org/10.5045/br.2014.49.1.36 Text en © 2014 Korean Society of Hematology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ahn, Heui June
Yoon, Dok-Hyun
Kim, Shin
Lee, Kyoungmin
Kang, EunHee
Huh, Jooryung
Park, Chan-Sik
Suh, Cheolwon
Primary mediastinal large B-cell lymphoma: a single-center experience in Korea
title Primary mediastinal large B-cell lymphoma: a single-center experience in Korea
title_full Primary mediastinal large B-cell lymphoma: a single-center experience in Korea
title_fullStr Primary mediastinal large B-cell lymphoma: a single-center experience in Korea
title_full_unstemmed Primary mediastinal large B-cell lymphoma: a single-center experience in Korea
title_short Primary mediastinal large B-cell lymphoma: a single-center experience in Korea
title_sort primary mediastinal large b-cell lymphoma: a single-center experience in korea
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974955/
https://www.ncbi.nlm.nih.gov/pubmed/24724065
http://dx.doi.org/10.5045/br.2014.49.1.36
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