A case of oxaliplatin-induced immune-mediated thrombocytopenia

Oxaliplatin is a platinum compound used in patients with gastrointestinal malignancies. It is known to evoke a drug-induced immune-mediated thrombocytopenia, which has not been reported in Korea. We describe a 53-year-old man who developed oxaliplatin-induced immune-mediated thrombocytopenia during...

Descripción completa

Detalles Bibliográficos
Autores principales: Suh, Seong Eun, Jang, Moon Ju, Chong, So Young, Aster, Richard H., Curtis, Brian R., Oh, Doyeun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974961/
https://www.ncbi.nlm.nih.gov/pubmed/24724069
http://dx.doi.org/10.5045/br.2014.49.1.61
_version_ 1782310074154221568
author Suh, Seong Eun
Jang, Moon Ju
Chong, So Young
Aster, Richard H.
Curtis, Brian R.
Oh, Doyeun
author_facet Suh, Seong Eun
Jang, Moon Ju
Chong, So Young
Aster, Richard H.
Curtis, Brian R.
Oh, Doyeun
author_sort Suh, Seong Eun
collection PubMed
description Oxaliplatin is a platinum compound used in patients with gastrointestinal malignancies. It is known to evoke a drug-induced immune-mediated thrombocytopenia, which has not been reported in Korea. We describe a 53-year-old man who developed oxaliplatin-induced immune-mediated thrombocytopenia during chemotherapy for colon cancer. Oxaliplatin-dependent IgG platelet antibodies were detected in his serum on flow cytometry. He was treated with immunoglobulin and corticosteroids without any complications. Physicians should consider oxaliplatin-induced immune-mediated thrombocytopenia, when a sudden, isolated thrombocytopenia develops during chemotherapy with oxaliplatin.
format Online
Article
Text
id pubmed-3974961
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis
record_format MEDLINE/PubMed
spelling pubmed-39749612014-04-10 A case of oxaliplatin-induced immune-mediated thrombocytopenia Suh, Seong Eun Jang, Moon Ju Chong, So Young Aster, Richard H. Curtis, Brian R. Oh, Doyeun Blood Res Case Report Oxaliplatin is a platinum compound used in patients with gastrointestinal malignancies. It is known to evoke a drug-induced immune-mediated thrombocytopenia, which has not been reported in Korea. We describe a 53-year-old man who developed oxaliplatin-induced immune-mediated thrombocytopenia during chemotherapy for colon cancer. Oxaliplatin-dependent IgG platelet antibodies were detected in his serum on flow cytometry. He was treated with immunoglobulin and corticosteroids without any complications. Physicians should consider oxaliplatin-induced immune-mediated thrombocytopenia, when a sudden, isolated thrombocytopenia develops during chemotherapy with oxaliplatin. Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis 2014-03 2014-03-24 /pmc/articles/PMC3974961/ /pubmed/24724069 http://dx.doi.org/10.5045/br.2014.49.1.61 Text en © 2014 Korean Society of Hematology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Suh, Seong Eun
Jang, Moon Ju
Chong, So Young
Aster, Richard H.
Curtis, Brian R.
Oh, Doyeun
A case of oxaliplatin-induced immune-mediated thrombocytopenia
title A case of oxaliplatin-induced immune-mediated thrombocytopenia
title_full A case of oxaliplatin-induced immune-mediated thrombocytopenia
title_fullStr A case of oxaliplatin-induced immune-mediated thrombocytopenia
title_full_unstemmed A case of oxaliplatin-induced immune-mediated thrombocytopenia
title_short A case of oxaliplatin-induced immune-mediated thrombocytopenia
title_sort case of oxaliplatin-induced immune-mediated thrombocytopenia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974961/
https://www.ncbi.nlm.nih.gov/pubmed/24724069
http://dx.doi.org/10.5045/br.2014.49.1.61
work_keys_str_mv AT suhseongeun acaseofoxaliplatininducedimmunemediatedthrombocytopenia
AT jangmoonju acaseofoxaliplatininducedimmunemediatedthrombocytopenia
AT chongsoyoung acaseofoxaliplatininducedimmunemediatedthrombocytopenia
AT asterrichardh acaseofoxaliplatininducedimmunemediatedthrombocytopenia
AT curtisbrianr acaseofoxaliplatininducedimmunemediatedthrombocytopenia
AT ohdoyeun acaseofoxaliplatininducedimmunemediatedthrombocytopenia
AT suhseongeun caseofoxaliplatininducedimmunemediatedthrombocytopenia
AT jangmoonju caseofoxaliplatininducedimmunemediatedthrombocytopenia
AT chongsoyoung caseofoxaliplatininducedimmunemediatedthrombocytopenia
AT asterrichardh caseofoxaliplatininducedimmunemediatedthrombocytopenia
AT curtisbrianr caseofoxaliplatininducedimmunemediatedthrombocytopenia
AT ohdoyeun caseofoxaliplatininducedimmunemediatedthrombocytopenia

Ejemplares similares