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Polymorphisms in the Human Inhibitory Signal-regulatory Protein α Do Not Affect Binding to Its Ligand CD47

CD47 is a widely distributed membrane protein that interacts with signal-regulatory protein α (SIRPα), an inhibitory receptor on myeloid cells that gives a “don't-eat-me” signal. Manipulation of the interaction is of considerable interest in the immunotherapy of cancer and in xenotransplantatio...

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Detalles Bibliográficos
Autores principales:	Hatherley, Deborah, Lea, Susan M., Johnson, Steven, Barclay, A. Neil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2014
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974974/ https://www.ncbi.nlm.nih.gov/pubmed/24550402 http://dx.doi.org/10.1074/jbc.M114.550558

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