Genome-wide parent-of-origin DNA methylation analysis reveals the intricacies of human imprinting and suggests a germline methylation-independent mechanism of establishment

Differential methylation between the two alleles of a gene has been observed in imprinted regions, where the methylation of one allele occurs on a parent-of-origin basis, the inactive X-chromosome in females, and at those loci whose methylation is driven by genetic variants. We have extensively char...

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Detalles Bibliográficos
Autores principales: Court, Franck, Tayama, Chiharu, Romanelli, Valeria, Martin-Trujillo, Alex, Iglesias-Platas, Isabel, Okamura, Kohji, Sugahara, Naoko, Simón, Carlos, Moore, Harry, Harness, Julie V., Keirstead, Hans, Sanchez-Mut, Jose Vicente, Kaneki, Eisuke, Lapunzina, Pablo, Soejima, Hidenobu, Wake, Norio, Esteller, Manel, Ogata, Tsutomu, Hata, Kenichiro, Nakabayashi, Kazuhiko, Monk, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975056/
https://www.ncbi.nlm.nih.gov/pubmed/24402520
http://dx.doi.org/10.1101/gr.164913.113

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