Cargando…
Nicotinic modulation of cortical circuits
The ascending cholinergic neuromodulatory system sends projections throughout cortex and has been shown to play an important role in a number of cognitive functions including arousal, working memory, and attention. However, despite a wealth of behavioral and anatomical data, understanding how cholin...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975109/ https://www.ncbi.nlm.nih.gov/pubmed/24734005 http://dx.doi.org/10.3389/fncir.2014.00030 |
_version_ | 1782310086527418368 |
---|---|
author | Arroyo, Sergio Bennett, Corbett Hestrin, Shaul |
author_facet | Arroyo, Sergio Bennett, Corbett Hestrin, Shaul |
author_sort | Arroyo, Sergio |
collection | PubMed |
description | The ascending cholinergic neuromodulatory system sends projections throughout cortex and has been shown to play an important role in a number of cognitive functions including arousal, working memory, and attention. However, despite a wealth of behavioral and anatomical data, understanding how cholinergic synapses modulate cortical function has been limited by the inability to selectively activate cholinergic axons. Now, with the development of optogenetic tools and cell-type specific Cre-driver mouse lines, it has become possible to stimulate cholinergic axons from the basal forebrain (BF) and probe cholinergic synapses in the cortex for the first time. Here we review recent work studying the cell-type specificity of nicotinic signaling in the cortex, synaptic mechanisms mediating cholinergic transmission, and the potential functional role of nicotinic modulation. |
format | Online Article Text |
id | pubmed-3975109 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-39751092014-04-14 Nicotinic modulation of cortical circuits Arroyo, Sergio Bennett, Corbett Hestrin, Shaul Front Neural Circuits Neuroscience The ascending cholinergic neuromodulatory system sends projections throughout cortex and has been shown to play an important role in a number of cognitive functions including arousal, working memory, and attention. However, despite a wealth of behavioral and anatomical data, understanding how cholinergic synapses modulate cortical function has been limited by the inability to selectively activate cholinergic axons. Now, with the development of optogenetic tools and cell-type specific Cre-driver mouse lines, it has become possible to stimulate cholinergic axons from the basal forebrain (BF) and probe cholinergic synapses in the cortex for the first time. Here we review recent work studying the cell-type specificity of nicotinic signaling in the cortex, synaptic mechanisms mediating cholinergic transmission, and the potential functional role of nicotinic modulation. Frontiers Media S.A. 2014-03-28 /pmc/articles/PMC3975109/ /pubmed/24734005 http://dx.doi.org/10.3389/fncir.2014.00030 Text en Copyright © 2014 Arroyo, Bennett and Hestrin. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Arroyo, Sergio Bennett, Corbett Hestrin, Shaul Nicotinic modulation of cortical circuits |
title | Nicotinic modulation of cortical circuits |
title_full | Nicotinic modulation of cortical circuits |
title_fullStr | Nicotinic modulation of cortical circuits |
title_full_unstemmed | Nicotinic modulation of cortical circuits |
title_short | Nicotinic modulation of cortical circuits |
title_sort | nicotinic modulation of cortical circuits |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975109/ https://www.ncbi.nlm.nih.gov/pubmed/24734005 http://dx.doi.org/10.3389/fncir.2014.00030 |
work_keys_str_mv | AT arroyosergio nicotinicmodulationofcorticalcircuits AT bennettcorbett nicotinicmodulationofcorticalcircuits AT hestrinshaul nicotinicmodulationofcorticalcircuits |