Cargando…
Efficacy of Ambroxol lozenges for pharyngitis: a meta-analysis
BACKGROUND: Ambroxol has a local anaesthetic action and is marketed for pain relief for sore throat. The objective is to examine the efficacy and safety of ambroxol for the relief of pain associated with acute uncomplicated sore throat. METHODS: A systematic review of the literature and meta-analysi...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975147/ https://www.ncbi.nlm.nih.gov/pubmed/24621446 http://dx.doi.org/10.1186/1471-2296-15-45 |
_version_ | 1782310093575946240 |
---|---|
author | Chenot, Jean-François Weber, Peter Friede, Tim |
author_facet | Chenot, Jean-François Weber, Peter Friede, Tim |
author_sort | Chenot, Jean-François |
collection | PubMed |
description | BACKGROUND: Ambroxol has a local anaesthetic action and is marketed for pain relief for sore throat. The objective is to examine the efficacy and safety of ambroxol for the relief of pain associated with acute uncomplicated sore throat. METHODS: A systematic review of the literature and meta-analysis. Selection criteria consisted of randomized controlled trials which compared ambroxol to placebo or any other treatment for sore throat. Two reviewers independently assessed for relevance, inclusion, and risk of bias. Weighted mean differences (WMDs) were calculated and are reported with corresponding 95% confidence intervals (CIs). RESULTS AND CONCLUSION: From 14 potentially relevant citations, five trials reported in three publications met the inclusion criteria, three of them were published twice. Ambroxol lozenges were compared in different dosages (5–30 mg) with mint flavoured lozenges and once with benzocaine. Main outcome was a ratio of pain reduction measured repeatedly over 3 h compared to baseline on 6-item verbal rating scale. A total of 1.772 adult patients participated in the trials. Pain intensity decreased in both study arms. A meta-analysis of the 5 controlled trials resulted in a difference in pain reduction compared to placebo of -0.11 (95% CI [-0.15, -0.07]; p < 0.0001) favouring ambroxol 20 mg. Quality of reporting of the studies was low. Ambroxol is slightly more effective in relieving pain in acute sore throat than mint flavoured lozenges over a period of 3 h. However, the additional benefits of ambroxol beyond three hours, remain unclear given that more than 50% of patients using mint flavoured lozenges for pain relief reported good or very good efficacy after 1 day compared to 69% with ambroxol. Ambroxol is a safe option for individual patients with mainly local symptoms asking for treatment. |
format | Online Article Text |
id | pubmed-3975147 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-39751472014-04-05 Efficacy of Ambroxol lozenges for pharyngitis: a meta-analysis Chenot, Jean-François Weber, Peter Friede, Tim BMC Fam Pract Research Article BACKGROUND: Ambroxol has a local anaesthetic action and is marketed for pain relief for sore throat. The objective is to examine the efficacy and safety of ambroxol for the relief of pain associated with acute uncomplicated sore throat. METHODS: A systematic review of the literature and meta-analysis. Selection criteria consisted of randomized controlled trials which compared ambroxol to placebo or any other treatment for sore throat. Two reviewers independently assessed for relevance, inclusion, and risk of bias. Weighted mean differences (WMDs) were calculated and are reported with corresponding 95% confidence intervals (CIs). RESULTS AND CONCLUSION: From 14 potentially relevant citations, five trials reported in three publications met the inclusion criteria, three of them were published twice. Ambroxol lozenges were compared in different dosages (5–30 mg) with mint flavoured lozenges and once with benzocaine. Main outcome was a ratio of pain reduction measured repeatedly over 3 h compared to baseline on 6-item verbal rating scale. A total of 1.772 adult patients participated in the trials. Pain intensity decreased in both study arms. A meta-analysis of the 5 controlled trials resulted in a difference in pain reduction compared to placebo of -0.11 (95% CI [-0.15, -0.07]; p < 0.0001) favouring ambroxol 20 mg. Quality of reporting of the studies was low. Ambroxol is slightly more effective in relieving pain in acute sore throat than mint flavoured lozenges over a period of 3 h. However, the additional benefits of ambroxol beyond three hours, remain unclear given that more than 50% of patients using mint flavoured lozenges for pain relief reported good or very good efficacy after 1 day compared to 69% with ambroxol. Ambroxol is a safe option for individual patients with mainly local symptoms asking for treatment. BioMed Central 2014-03-13 /pmc/articles/PMC3975147/ /pubmed/24621446 http://dx.doi.org/10.1186/1471-2296-15-45 Text en Copyright © 2014 Chenot et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. |
spellingShingle | Research Article Chenot, Jean-François Weber, Peter Friede, Tim Efficacy of Ambroxol lozenges for pharyngitis: a meta-analysis |
title | Efficacy of Ambroxol lozenges for pharyngitis: a meta-analysis |
title_full | Efficacy of Ambroxol lozenges for pharyngitis: a meta-analysis |
title_fullStr | Efficacy of Ambroxol lozenges for pharyngitis: a meta-analysis |
title_full_unstemmed | Efficacy of Ambroxol lozenges for pharyngitis: a meta-analysis |
title_short | Efficacy of Ambroxol lozenges for pharyngitis: a meta-analysis |
title_sort | efficacy of ambroxol lozenges for pharyngitis: a meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975147/ https://www.ncbi.nlm.nih.gov/pubmed/24621446 http://dx.doi.org/10.1186/1471-2296-15-45 |
work_keys_str_mv | AT chenotjeanfrancois efficacyofambroxollozengesforpharyngitisametaanalysis AT weberpeter efficacyofambroxollozengesforpharyngitisametaanalysis AT friedetim efficacyofambroxollozengesforpharyngitisametaanalysis |