Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer

In colon cancer, mutation of the Wnt repressor Adenomatous polyposis coli (APC) leads to a state of aberrant and unrestricted “high-activity” signaling. However, relevance of high Wnt tone in non-genetic human disease is unknown. Here we demonstrate that distinct Wnt activity functional states deter...

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Detalles Bibliográficos
Autores principales: Fancy, Stephen P.J., Harrington, Emily P., Baranzini, Sergio E., Silbereis, John C., Shiow, Lawrence R., Yuen, Tracy J., Huang, Eric J., Lomvardas, Stavros, Rowitch, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975168/
https://www.ncbi.nlm.nih.gov/pubmed/24609463
http://dx.doi.org/10.1038/nn.3676

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975168/
https://www.ncbi.nlm.nih.gov/pubmed/24609463
http://dx.doi.org/10.1038/nn.3676

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