Exercise Pretreatment Promotes Mitochondrial Dynamic Protein OPA1 Expression after Cerebral Ischemia in Rats

Exercise training is a neuroprotective strategy in cerebral ischemic injury, but the underlying mechanisms are not yet clear. In the present study, we investigated the effects of treadmill exercise pretreatment on the expression of mitochondrial dynamic proteins. We examined the expression of OPA1/D...

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Detalles Bibliográficos
Autores principales: Zhang, Li, He, Zhijie, Zhang, Qi, Wu, Yi, Yang, Xiaojiao, Niu, Wenxiu, Hu, Yongshan, Jia, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975407/
https://www.ncbi.nlm.nih.gov/pubmed/24633199
http://dx.doi.org/10.3390/ijms15034453
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author Zhang, Li
He, Zhijie
Zhang, Qi
Wu, Yi
Yang, Xiaojiao
Niu, Wenxiu
Hu, Yongshan
Jia, Jie
author_facet Zhang, Li
He, Zhijie
Zhang, Qi
Wu, Yi
Yang, Xiaojiao
Niu, Wenxiu
Hu, Yongshan
Jia, Jie
author_sort Zhang, Li
collection PubMed
description Exercise training is a neuroprotective strategy in cerebral ischemic injury, but the underlying mechanisms are not yet clear. In the present study, we investigated the effects of treadmill exercise pretreatment on the expression of mitochondrial dynamic proteins. We examined the expression of OPA1/DLP1/MFF/Mfn1/Mfn2, which regulatesmitochondrial fusion and fission, and cytochrome C oxidase subunits (COX subunits), which regulatemitochondrial functions, after middle cerebral artery occlusion (MCAO) in rats. T2-weighted magnetic resonance imaging (MRI) was evaluated as indices of brain edema after ischemia as well. Treadmill training pretreatment increased the expression levels of OPA1 and COXII/III/IV and alleviated brain edema, indicating that exercise pretreatment provided neuroprotection in cerebral ischemic injury via the regulation of mitochondrial dynamics and functions.
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spelling pubmed-39754072014-04-04 Exercise Pretreatment Promotes Mitochondrial Dynamic Protein OPA1 Expression after Cerebral Ischemia in Rats Zhang, Li He, Zhijie Zhang, Qi Wu, Yi Yang, Xiaojiao Niu, Wenxiu Hu, Yongshan Jia, Jie Int J Mol Sci Article Exercise training is a neuroprotective strategy in cerebral ischemic injury, but the underlying mechanisms are not yet clear. In the present study, we investigated the effects of treadmill exercise pretreatment on the expression of mitochondrial dynamic proteins. We examined the expression of OPA1/DLP1/MFF/Mfn1/Mfn2, which regulatesmitochondrial fusion and fission, and cytochrome C oxidase subunits (COX subunits), which regulatemitochondrial functions, after middle cerebral artery occlusion (MCAO) in rats. T2-weighted magnetic resonance imaging (MRI) was evaluated as indices of brain edema after ischemia as well. Treadmill training pretreatment increased the expression levels of OPA1 and COXII/III/IV and alleviated brain edema, indicating that exercise pretreatment provided neuroprotection in cerebral ischemic injury via the regulation of mitochondrial dynamics and functions. Molecular Diversity Preservation International (MDPI) 2014-03-13 /pmc/articles/PMC3975407/ /pubmed/24633199 http://dx.doi.org/10.3390/ijms15034453 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Zhang, Li
He, Zhijie
Zhang, Qi
Wu, Yi
Yang, Xiaojiao
Niu, Wenxiu
Hu, Yongshan
Jia, Jie
Exercise Pretreatment Promotes Mitochondrial Dynamic Protein OPA1 Expression after Cerebral Ischemia in Rats
title Exercise Pretreatment Promotes Mitochondrial Dynamic Protein OPA1 Expression after Cerebral Ischemia in Rats
title_full Exercise Pretreatment Promotes Mitochondrial Dynamic Protein OPA1 Expression after Cerebral Ischemia in Rats
title_fullStr Exercise Pretreatment Promotes Mitochondrial Dynamic Protein OPA1 Expression after Cerebral Ischemia in Rats
title_full_unstemmed Exercise Pretreatment Promotes Mitochondrial Dynamic Protein OPA1 Expression after Cerebral Ischemia in Rats
title_short Exercise Pretreatment Promotes Mitochondrial Dynamic Protein OPA1 Expression after Cerebral Ischemia in Rats
title_sort exercise pretreatment promotes mitochondrial dynamic protein opa1 expression after cerebral ischemia in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975407/
https://www.ncbi.nlm.nih.gov/pubmed/24633199
http://dx.doi.org/10.3390/ijms15034453
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