8-Alkylcoumarins from the Fruits of Cnidium monnieri Protect against Hydrogen Peroxide Induced Oxidative Stress Damage

Three new 8-alkylcoumarins, 7-O-methylphellodenol-B (1), 7-methoxy-8-(3-methyl-2,3-epoxy-1-oxobutyl)chromen-2-one (2), and 3′-O-methylvaginol (3), together with seven known compounds (4–10) were isolated from the fruits of Cnidium monnieri. Their structures were determined by detailed analysis of sp...

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Autores principales: Chang, Chi-I, Hu, Wan-Chiao, Shen, Che-Piao, Hsu, Ban-Dar, Lin, Wei-Yong, Sung, Ping-Jyun, Wang, Wei-Hsien, Wu, Jin-Bin, Kuo, Yueh-Hsiung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975416/
https://www.ncbi.nlm.nih.gov/pubmed/24642881
http://dx.doi.org/10.3390/ijms15034608
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author Chang, Chi-I
Hu, Wan-Chiao
Shen, Che-Piao
Hsu, Ban-Dar
Lin, Wei-Yong
Sung, Ping-Jyun
Wang, Wei-Hsien
Wu, Jin-Bin
Kuo, Yueh-Hsiung
author_facet Chang, Chi-I
Hu, Wan-Chiao
Shen, Che-Piao
Hsu, Ban-Dar
Lin, Wei-Yong
Sung, Ping-Jyun
Wang, Wei-Hsien
Wu, Jin-Bin
Kuo, Yueh-Hsiung
author_sort Chang, Chi-I
collection PubMed
description Three new 8-alkylcoumarins, 7-O-methylphellodenol-B (1), 7-methoxy-8-(3-methyl-2,3-epoxy-1-oxobutyl)chromen-2-one (2), and 3′-O-methylvaginol (3), together with seven known compounds (4–10) were isolated from the fruits of Cnidium monnieri. Their structures were determined by detailed analysis of spectroscopic data and comparison with the data of known analogues. All the isolates were evaluated the cytoprotective activity by MTS cell proliferation assay and the results showed that all the three new 8-alkylcoumarins exhibited cytoprotective effect on Neuro-2a neuroblastoma cells injured by hydrogen peroxide.
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spelling pubmed-39754162014-04-04 8-Alkylcoumarins from the Fruits of Cnidium monnieri Protect against Hydrogen Peroxide Induced Oxidative Stress Damage Chang, Chi-I Hu, Wan-Chiao Shen, Che-Piao Hsu, Ban-Dar Lin, Wei-Yong Sung, Ping-Jyun Wang, Wei-Hsien Wu, Jin-Bin Kuo, Yueh-Hsiung Int J Mol Sci Article Three new 8-alkylcoumarins, 7-O-methylphellodenol-B (1), 7-methoxy-8-(3-methyl-2,3-epoxy-1-oxobutyl)chromen-2-one (2), and 3′-O-methylvaginol (3), together with seven known compounds (4–10) were isolated from the fruits of Cnidium monnieri. Their structures were determined by detailed analysis of spectroscopic data and comparison with the data of known analogues. All the isolates were evaluated the cytoprotective activity by MTS cell proliferation assay and the results showed that all the three new 8-alkylcoumarins exhibited cytoprotective effect on Neuro-2a neuroblastoma cells injured by hydrogen peroxide. Molecular Diversity Preservation International (MDPI) 2014-03-17 /pmc/articles/PMC3975416/ /pubmed/24642881 http://dx.doi.org/10.3390/ijms15034608 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Chang, Chi-I
Hu, Wan-Chiao
Shen, Che-Piao
Hsu, Ban-Dar
Lin, Wei-Yong
Sung, Ping-Jyun
Wang, Wei-Hsien
Wu, Jin-Bin
Kuo, Yueh-Hsiung
8-Alkylcoumarins from the Fruits of Cnidium monnieri Protect against Hydrogen Peroxide Induced Oxidative Stress Damage
title 8-Alkylcoumarins from the Fruits of Cnidium monnieri Protect against Hydrogen Peroxide Induced Oxidative Stress Damage
title_full 8-Alkylcoumarins from the Fruits of Cnidium monnieri Protect against Hydrogen Peroxide Induced Oxidative Stress Damage
title_fullStr 8-Alkylcoumarins from the Fruits of Cnidium monnieri Protect against Hydrogen Peroxide Induced Oxidative Stress Damage
title_full_unstemmed 8-Alkylcoumarins from the Fruits of Cnidium monnieri Protect against Hydrogen Peroxide Induced Oxidative Stress Damage
title_short 8-Alkylcoumarins from the Fruits of Cnidium monnieri Protect against Hydrogen Peroxide Induced Oxidative Stress Damage
title_sort 8-alkylcoumarins from the fruits of cnidium monnieri protect against hydrogen peroxide induced oxidative stress damage
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975416/
https://www.ncbi.nlm.nih.gov/pubmed/24642881
http://dx.doi.org/10.3390/ijms15034608
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