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Application of Computational Methods for the Design of BACE-1 Inhibitors: Validation of in Silico Modelling

β-Secretase (BACE-1) constitutes an important target for search of anti-Alzheimer’s drugs. The first inhibitors of this enzyme were peptidic compounds with high molecular weight and low bioavailability. Therefore, the search for new efficient non-peptidic inhibitors has been undertaken by many scien...

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Detalles Bibliográficos
Autores principales:	Bajda, Marek, Jończyk, Jakub, Malawska, Barbara, Filipek, Sławomir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Diversity Preservation International (MDPI) 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975444/ https://www.ncbi.nlm.nih.gov/pubmed/24663084 http://dx.doi.org/10.3390/ijms15035128

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