Abundance of Aβ(5-x) like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer’s disease

BACKGROUND: According to the modified amyloid hypothesis the main event in the pathogenesis of Alzheimer’s disease (AD) is the deposition of neurotoxic amyloid β-peptide (Aβ) within neurons. Additionally to full-length peptides, a great diversity of N-truncated Aβ variants is derived from the larger...

Descripción completa

Detalles Bibliográficos
Autores principales: Guzmán, Erika Avendaño, Bouter, Yvonne, Richard, Bernhard C, Lannfelt, Lars, Ingelsson, Martin, Paetau, Anders, Verkkoniemi-Ahola, Auli, Wirths, Oliver, Bayer, Thomas A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975588/
https://www.ncbi.nlm.nih.gov/pubmed/24694184
http://dx.doi.org/10.1186/1750-1326-9-13

Ejemplares similares

Ejemplares similares