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Discrepancy between the Clinical Image and Pathological Findings of Non-Small Cell Lung Cancer Harboring an Epidermal Growth Factor Receptor Gene Mutation That Was Surgically Resected after Gefitinib Treatment
We herein describe a discrepancy between the clinical image and pathological findings in a non-small cell lung cancer patient with an epidermal growth factor receptor (EGFR) mutation who underwent surgical resection after gefitinib treatment. The patient was a 66-year-old female with c-stage IIIA lu...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975753/ https://www.ncbi.nlm.nih.gov/pubmed/24707260 http://dx.doi.org/10.1159/000360154 |
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author | Chikaishi, Yasuhiro Uramoto, Hidetaka Oka, Soichi Nagata, Shuya Shimokawa, Hidehiko So, Tomoko Yamada, Sohsuke Hanagiri, Takeshi Mukae, Hiroshi Tanaka, Fumihiro |
author_facet | Chikaishi, Yasuhiro Uramoto, Hidetaka Oka, Soichi Nagata, Shuya Shimokawa, Hidehiko So, Tomoko Yamada, Sohsuke Hanagiri, Takeshi Mukae, Hiroshi Tanaka, Fumihiro |
author_sort | Chikaishi, Yasuhiro |
collection | PubMed |
description | We herein describe a discrepancy between the clinical image and pathological findings in a non-small cell lung cancer patient with an epidermal growth factor receptor (EGFR) mutation who underwent surgical resection after gefitinib treatment. The patient was a 66-year-old female with c-stage IIIA lung adenocarcinoma harboring an EGFR gene mutation; she was surgically treated after receiving gefitinib. The pathological examination revealed adenocarcinoma, and the pathologically therapeutic effect was considered to be slight or of no response. EGFR T790M mutation and MET amplification were not present. The pathologically therapeutic effect is generally well correlated with the response rate after induction therapy. In this case, there was a discrepancy between the clinical image and pathological findings. Our findings, therefore, raise questions about the role of surgery after EGFR-tyrosine kinase inhibitor treatment. |
format | Online Article Text |
id | pubmed-3975753 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-39757532014-04-04 Discrepancy between the Clinical Image and Pathological Findings of Non-Small Cell Lung Cancer Harboring an Epidermal Growth Factor Receptor Gene Mutation That Was Surgically Resected after Gefitinib Treatment Chikaishi, Yasuhiro Uramoto, Hidetaka Oka, Soichi Nagata, Shuya Shimokawa, Hidehiko So, Tomoko Yamada, Sohsuke Hanagiri, Takeshi Mukae, Hiroshi Tanaka, Fumihiro Case Rep Oncol Published online: February, 2014 We herein describe a discrepancy between the clinical image and pathological findings in a non-small cell lung cancer patient with an epidermal growth factor receptor (EGFR) mutation who underwent surgical resection after gefitinib treatment. The patient was a 66-year-old female with c-stage IIIA lung adenocarcinoma harboring an EGFR gene mutation; she was surgically treated after receiving gefitinib. The pathological examination revealed adenocarcinoma, and the pathologically therapeutic effect was considered to be slight or of no response. EGFR T790M mutation and MET amplification were not present. The pathologically therapeutic effect is generally well correlated with the response rate after induction therapy. In this case, there was a discrepancy between the clinical image and pathological findings. Our findings, therefore, raise questions about the role of surgery after EGFR-tyrosine kinase inhibitor treatment. S. Karger AG 2014-02-20 /pmc/articles/PMC3975753/ /pubmed/24707260 http://dx.doi.org/10.1159/000360154 Text en Copyright © 2014 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions. |
spellingShingle | Published online: February, 2014 Chikaishi, Yasuhiro Uramoto, Hidetaka Oka, Soichi Nagata, Shuya Shimokawa, Hidehiko So, Tomoko Yamada, Sohsuke Hanagiri, Takeshi Mukae, Hiroshi Tanaka, Fumihiro Discrepancy between the Clinical Image and Pathological Findings of Non-Small Cell Lung Cancer Harboring an Epidermal Growth Factor Receptor Gene Mutation That Was Surgically Resected after Gefitinib Treatment |
title | Discrepancy between the Clinical Image and Pathological Findings of Non-Small Cell Lung Cancer Harboring an Epidermal Growth Factor Receptor Gene Mutation That Was Surgically Resected after Gefitinib Treatment |
title_full | Discrepancy between the Clinical Image and Pathological Findings of Non-Small Cell Lung Cancer Harboring an Epidermal Growth Factor Receptor Gene Mutation That Was Surgically Resected after Gefitinib Treatment |
title_fullStr | Discrepancy between the Clinical Image and Pathological Findings of Non-Small Cell Lung Cancer Harboring an Epidermal Growth Factor Receptor Gene Mutation That Was Surgically Resected after Gefitinib Treatment |
title_full_unstemmed | Discrepancy between the Clinical Image and Pathological Findings of Non-Small Cell Lung Cancer Harboring an Epidermal Growth Factor Receptor Gene Mutation That Was Surgically Resected after Gefitinib Treatment |
title_short | Discrepancy between the Clinical Image and Pathological Findings of Non-Small Cell Lung Cancer Harboring an Epidermal Growth Factor Receptor Gene Mutation That Was Surgically Resected after Gefitinib Treatment |
title_sort | discrepancy between the clinical image and pathological findings of non-small cell lung cancer harboring an epidermal growth factor receptor gene mutation that was surgically resected after gefitinib treatment |
topic | Published online: February, 2014 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975753/ https://www.ncbi.nlm.nih.gov/pubmed/24707260 http://dx.doi.org/10.1159/000360154 |
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