Peptide deformylase inhibitor actinonin reduces celastrol’s HSP70 induction while synergizing proliferation inhibition in tumor cells

BACKGROUND: Celastrol is a promising anti-tumor agent, yet it also elevates heat shock proteins (HSPs), especially HSP70, this effect believed to reduce its anti-tumor effects. Concurrent use of siRNA to increase celastrol’s anti-tumor effects through HSP70 interference has been reported, but becaus...

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Detalles Bibliográficos
Autores principales: Peng, Bin, Zhang, Xue, Cao, Fanfan, Wang, Ying, Xu, Limin, Cao, Lu, Yang, Chunxin, Li, Maoquan, Uzan, Georges, Zhang, Denghai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975845/
https://www.ncbi.nlm.nih.gov/pubmed/24589236
http://dx.doi.org/10.1186/1471-2407-14-146

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