Activation of brain indoleamine 2,3-dioxygenase contributes to epilepsy-associated depressive-like behavior in rats with chronic temporal lobe epilepsy

BACKGROUND: Depression has most often been diagnosed in patients with temporal lobe epilepsy (TLE), but the mechanism underlying this association remains unclear. In this study, we report that indoleamine 2,3-dioxygenase 1 (IDO1), a rate-limiting enzyme in tryptophan metabolism, plays a key role in...

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Detalles Bibliográficos
Autores principales: Xie, Wei, Cai, Lun, Yu, Yunhong, Gao, Liang, Xiao, Limin, He, Qianchao, Ren, Zhijun, Liu, Yuanzheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975854/
https://www.ncbi.nlm.nih.gov/pubmed/24594021
http://dx.doi.org/10.1186/1742-2094-11-41

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