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Tuberous-sclerosis complex-related cell signaling in the pathogenesis of lung cancer
BACKGROUND: Hamartin (TSC1) and tuberin (TSC2), encoded by the tuberous sclerosis complex (TSC) genes, form a tumor-suppressor heterodimer which is implicated in PI3K-Akt signaling and acts as a functional inhibitor of the mammalian target of rapamycin (mTOR). Dysregulation of mTOR has been assigned...
Autores principales: | Fuchs, Angela, König, Katharina, Heukamp, Lukas C, Fassunke, Jana, Kirfel, Jutta, Huss, Sebastian, Becker, Albert J, Büttner, Reinhard, Majores, Michael |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975884/ https://www.ncbi.nlm.nih.gov/pubmed/24593867 http://dx.doi.org/10.1186/1746-1596-9-48 |
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