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Pharmacological considerations in the design of anti-malarial drug combination therapies – is matching half-lives enough?
Anti-malarial drugs are now mainly deployed as combination therapy (CT), primarily as a mechanism to prevent or slow the spread of resistance. This strategy is justified by mathematical arguments that generally assume that drug ‘resistance’ is a binary all-or-nothing genetic trait. Herein, a pharmac...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975950/ https://www.ncbi.nlm.nih.gov/pubmed/24552440 http://dx.doi.org/10.1186/1475-2875-13-62 |