Transient paradoxical bronchospasm associated with inhalation of the LAMA AZD9164: analysis of two Phase I, randomised, double-blind, placebo-controlled studies

BACKGROUND: AZD9164 has demonstrated potential as an inhaled, long-acting, muscarinic antagonist (LAMA) bronchodilator. However, in patients with COPD, but not in healthy subjects, a transient initial drop in FEV(1) was observed following inhalation of nebulised doses of AZD9164 in citrate buffer. T...

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Detalles Bibliográficos
Autores principales: Jorup, Carin, Bengtsson, Thomas, Strandgården, Kerstin, Sjöbring, Ulf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976047/
https://www.ncbi.nlm.nih.gov/pubmed/24669829
http://dx.doi.org/10.1186/1471-2466-14-52

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976047/
https://www.ncbi.nlm.nih.gov/pubmed/24669829
http://dx.doi.org/10.1186/1471-2466-14-52

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